Evidence map›Paper›PMID 41803566›Full record

ArticleCell biology and toxicology2026

Gomisin B promotes RSL3-induced ferroptosis in neuroblastoma by inhibiting the ESR1/USP7/SREBF1 axis.

Mengyao Dong, Ting Gao, Yongtao Xu, Qinghao Li, Zhaolong Ma, Bin Zhao, Ming Ming

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mengyao DongDepartment of Neonatology, The Affiliated Taian City Central Hospital of Qingdao University, Shandong, Taian, 271000, People's Republic of China.
Ting GaoCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China.
Yongtao XuCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China.
Qinghao LiCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China.
Zhaolong MaCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China.
Bin ZhaoCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China. zhaobin29@qdu.edu.cn.
Ming MingCenter of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, Taishan District, Longtan Road 29, Shandong, Taian, 271000, People's Republic of China. mingming@qdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGomisin B was reported to alleviate neuroblastoma (NB) progression, and the promotion of ferroptosis also inhibited NB. This study aimed to investigate the mechanism by which Gomisin B regulates ESR1 to affect ferroptosis in NB.

methodsSH-SY5Y and IMR-32 cells were induced to ferroptosis by RSL3 and treated with Gomisin B. Co-IP was utilized to probe the relationship between USP7 and SREBF1. The interaction between ESR1 and USP7 was tested by dual luciferase reporter and ChIP. In addition, cell viability was assessed via CCK-8. Commercial kits were implemented to determine the MDA, GSH, Fe

resultsGomisin B promoted ferroptosis in NB cells and overexpression of ESR1 reversed this phenomenon. Additionally, ESR1 transcriptionally activated USP7 by interacting with the USP7 promoter to inhibit NB cell ferroptosis. USP7 facilitated SREBF1 deubiquitination by binding to SREBF1, thereby enhancing its protein stability. Gomisin B regulated the ESR1/USP7/SREBF1 axis to promote ferroptosis in NB cells. Finally, it was verified at the animal level that Gomisin B promoted ferroptosis and inhibited tumor growth in NB tumor-bearing nude mice.

conclusionGomisin B inhibited the transcriptional activation of USP7 by downregulating ESR1, thereby suppressing the deubiquitination of SREBF1. This enhanced NB ferroptosis to alleviate NB progression.

Indexed as

Estrogen Receptor alphaFerroptosisNeuroblastomaSterol Regulatory Element Binding Protein 1Ubiquitin-Specific Peptidase 7AnimalsCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudeEstrogen Receptor alphaSREBF1 protein, humanSterol Regulatory Element Binding Protein 1Ubiquitin-Specific Peptidase 7ESR1FerroptosisNeuroblastomaSREBF1USP7

Identifiers

PMID41803566
PMCPMC13149567

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.