ArticleHeredity2026
How population subsampling to concentrate selection effects can help to find epistatic interactions of transmission ratio distortion.
Article in Heredity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene-gene incompatibilities-caused by deleterious allele combinations at different loci - can impair gametophyte or zygote viability, reducing fertility or overall viability in hybrids or hybrid-derived populations. These incompatibilities can be detected through transmission ratio distortion (TRD), which reflects deviations from Mendelian inheritance due to selection against incompatible allele combinations. However, identifying epistatic TRD locus pairs remains challenging, as standard multiple-testing approaches are underpowered. To address this limitation, a stepwise workflow is introduced that achieves higher sensitivity than standard approaches by using targeted subsampling of the population. This strategy effectively concentrates TRD signals shared between two interacting loci into a single locus, thereby strengthening the signal, simplifying the analysis, and eliminating the need for multiple-testing correction. In addition, incompatibility models were developed to predict TRD patterns under various selection mechanisms (gametophytic or zygotic) and inheritance modes (symmetric or asymmetric) across common mapping populations (F2, BC1, RIL). Applied to 17 F2 and 2 RIL intraspecific Arabidopsis thaliana populations, the stepwise workflow identified seven novel and two known TRD locus pairs. In most cases, the observed TRD patterns offered insights into potential selection mechanisms. The demonstrated sensitivity and robustness of the proposed method highlight its potential to uncover numerous additional incompatibility locus pairs across diverse species. Systematic application of the method could elevate the discovery of hybrid incompatibilities beyond current incidental discoveries and open new avenues for understanding the genetic architecture of speciation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.