Evidence map›Paper›PMID 41803465›Full record

ArticleJournal of computer-aided molecular design2026

Molecular mechanism of aspartame recognition by the human sweet taste receptor T1R2-T1R3 revealed by homology modeling and molecular dynamics simulations.

Mingqiong Tong, Shengqi Duan, Lanlan Wang, Yuewen Yin, Lin Chen, Yanyan Zhao, Bo Liu, Xiangling Gu, Zanxia Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingqiong TongShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China. tongmingqiong@163.com.
Shengqi DuanShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China.
Lanlan WangShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China.
Yuewen YinInstitute of Biophysics, Dezhou University, Dezhou, 253023, China.
Lin ChenShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China.
Yanyan ZhaoShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China.
Bo LiuDepartment of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, Shandong, China. ertrdfgg@qlu.edu.cn.
Xiangling GuShandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Health and Medicine, Dezhou University, Decheng District, Dezhou, 253023, China. xlgu@dzu.edu.cn.
Zanxia CaoInstitute of Biophysics, Dezhou University, Dezhou, 253023, China. qiayilai@mail.ustc.edu.cn.

Funding

National Natural Science Foundation of China 22375028National Natural Science Foundation of China 32571444National Natural Science Foundation of China 82572905Natural Science Foundation of Shandong Province ZR2023QB247
6 · The paper itself

Abstract

Aspartame is widely used as a noncaloric artificial sweetener in the food industry. Aspartame exists in two conformations, L-type and E-type, and its binding affinity to the T1R2 subunit of the human sweet taste receptor T1R2-T1R3 is highly susceptible to its conformational variability. In this study, homology modeling was performed using the GABA

Indexed as

AspartameMolecular Dynamics SimulationReceptors, G-Protein-CoupledSweetening AgentsAmino Acid SequenceBinding SitesHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsProtein BindingProtein ConformationSucroseAspartameReceptors, G-Protein-CoupledSucroseSweetening Agentstaste receptors, type 1trichlorosucroseAspartameConformational flexibilityHomology modelingHuman sweet taste receptorMolecular dynamics simulation

Identifiers

PMID41803465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.