Evidence map›Paper›PMID 41803427›Full record

ArticleGeroScience2026

Graded normobaric hypoxia alters cerebral oxygenation and cognition in middle-aged adults: a single-blind counterbalanced randomized crossover trial.

Ayoub Boulares, Corentin Faucher, Manuel Gimenes, Dimitri Theurot, Aurélien Pichon, Olivier Dupuy

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayoub BoularesLaboratory MOVE (UR 20296, Faculty of Sport Sciences (STAPS), University of Poitiers, Poitiers, France. ayoub.boulares@univ-poitiers.fr.ORCID http://orcid.org/0009-0007-5728-9801
Corentin FaucherLaboratory MOVE (UR 20296, Faculty of Sport Sciences (STAPS), University of Poitiers, Poitiers, France.
Manuel GimenesLaboratory CeRCA, University of Poitiers, Poitiers, France.
Dimitri TheurotDepartment of Environmental and Occupational Health, Université de Montréal, Montreal, QC, Canada.
Aurélien Pichon *Laboratory MOVE (UR 20296, Faculty of Sport Sciences (STAPS), University of Poitiers, Poitiers, France. aurelien.pichon@univ-poitiers.fr.ORCID http://orcid.org/0000-0003-2772-9232
Olivier Dupuy *Laboratory MOVE (UR 20296, Faculty of Sport Sciences (STAPS), University of Poitiers, Poitiers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with reduced cerebrovascular reactivity and impaired neurovascular coupling, limiting the brain's ability to maintain adequate oxygen delivery during physiological stressors such as hypoxia. These vascular changes may heighten middle-aged adults' vulnerability to hypoxia-induced neural and cognitive impairments, yet dose-response data integrating cerebral oxygenation and cognition remain scarce. In a single-blind, randomized crossover trial, 16 participants completed four normobaric sessions (45-65 min each) at different FiO

Indexed as

Acute hypoxiaAgingCerebral oxygenationCognitive performanceNear-infrared spectroscopyNormobaric hypoxia

Identifiers

PMID41803427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.