Evidence map›Paper›PMID 41803355›Full record

SynthesisCurrent nutrition reports2026

Hypersensitivity to Intravenous Lipid Emulsions and Food Allergies: a Systematic Review of Case Reports.

Chanita Unhapipatpong, Narachai Julanon, Mongkhon Sompornrattanaphan, Katherine Schwenger, Ann MacGillivray, Meredith Barwin, Lesley Graham, Paul Lee, Johane P Allard

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current nutrition reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chanita UnhapipatpongDivision of Nutrition, Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.ORCID http://orcid.org/0000-0003-1525-5615
Narachai JulanonDivision of Dermatology, Department of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.ORCID http://orcid.org/0000-0002-4374-1170
Mongkhon SompornrattanaphanDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID http://orcid.org/0000-0001-8419-0873
Katherine SchwengerDivision of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Ann MacGillivrayToronto General Hospital, University of Toronto, Toronto, Canada.
Meredith BarwinToronto General Hospital, University of Toronto, Toronto, Canada.
Lesley GrahamToronto General Hospital, University of Toronto, Toronto, Canada.
Paul LeeToronto General Hospital, University of Toronto, Toronto, Canada.
Johane P AllardDivision of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, ON, Canada. dr.johane.allard@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of the reviewIntravenous lipid emulsion (ILE) is essential for patients with prolonged intestinal failure but may contain potential allergens. Unnecessary avoidance of ILE in patients with food allergies could limit nutritional options. Therefore, we systematically reviewed the evidence on ILE use in patients with and without food allergies, including those who experienced hypersensitivity reactions. Searches were conducted in Medline, Scopus, Web of Science, Google Scholar, and the Canada Vigilance Adverse Reaction Database through April 30, 2025. RECENT

findingsTwenty-eight individual cases (from 25 reports) met the inclusion criteria, involving 10 pediatric and 18 adult patients. The median time to hypersensitivity reaction was 5 min (IQR 0–45) in children and 60 min (IQR 15–120) in adults. The median cumulative exposure before reaction was 1.5 days (IQR 1–11) in children and 1 day (IQR 1–1) in adults. Anaphylaxis (50.0%) and cutaneous manifestations (42.9%) were the most common reactions. Of the 28 patients, 5 (17.9%) had known food allergies and experienced hypersensitivity to ILE. Among all patients, 4 of 6 (66.7%) who underwent skin testing had negative results; however, 3 of these 4 reacted upon ILE rechallenge. ILE-associated hypersensitivity reactions can occur in both food-allergic and non–food-allergic patients, particularly within the first day of administration. Skin testing for ILE allergy has limited reliability, and diagnostic confirmation is uncommon due to the lack of a standardized allergy evaluation. Individualized risk assessment and selective use of lipid formulations are essential to minimize risk. ILE rechallenge should be performed under the supervision of an immunologist.

Indexed as

Drug HypersensitivityFat Emulsions, IntravenousFood HypersensitivityAdultAllergensAnaphylaxisChildHumansSkin TestsAllergensFat Emulsions, IntravenousCross-reactivityEgg allergyFish allergyFood allergyHypersensitivityIntravenous lipid emulsionPeanut allergySoybean allergy

Identifiers

PMID41803355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.