Evidence map›Paper›PMID 41803318›Full record

ArticleNature neuroscience2026

A neural signature of adaptive mentalization.

Niklas Buergi, Gökhan Aydogan, Arkady Konovalov, Christian C Ruff

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Neural mechanisms underlying decisions to express or suppress emotions.Social cognitive and affective neuroscience · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Niklas Buergi *Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland. niklas.g.buergi@gmail.com.ORCID http://orcid.org/0000-0002-9783-5631
Gökhan Aydogan *Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland. goekhan.aydogan@econ.uzh.ch.ORCID http://orcid.org/0000-0003-2187-7912
Arkady KonovalovZurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9448-6659
Christian C RuffZurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland. christian.ruff@econ.uzh.ch.ORCID http://orcid.org/0000-0002-3964-2364

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 725355Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 10.006.863
6 · The paper itself

Abstract

Mentalization, inferring others' emotions and intentions, is crucial for human social interactions and is impaired in various brain disorders. While previous neuroscience research has focused on static mentalization strategies, we know little about how the brain adaptively selects which strategies to use at any given moment. Here we investigate this core aspect of mentalization with computational modeling and functional magnetic resonance imaging (fMRI) during interactive strategic games. We find that most participants can adapt their strategies to the changing sophistication of their opponents, though there are considerable individual differences. Model-based fMRI analyses identify a distributed brain network in which activity and connectivity track this mentalization-belief adaptation. The extent to which people update their beliefs about others' sophistication can be predicted out of sample from neural activity, providing a neural signature of adaptive mentalization. Our model elucidates the neural basis of mentalization ability and provides a method for assessing these capabilities in healthy and clinical populations.

Indexed as

Adaptation, PsychologicalBrainMentalizationTheory of MindBrain MappingFemaleHumansMagnetic Resonance ImagingMaleModels, Neurological

Identifiers

PMID41803318
PMCPMC13061600

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.