Observational studyJournal of human hypertension2026
Association between hemoglobin and all-cause mortality in patients with obstructive sleep apnea and hypertension: insights from an observational study.
Observational study in Journal of human hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hemoglobin, oxygen transport reserve, and risk in hypertensive obstructive sleep apnea.Journal of human hypertension · 2026Article
- Systemic inflammatory response index is associated with increased all-cause and cardiovascular mortality in obstructive sleep apnea: evidence from NHANES and validation with an external hospital-based dataset.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is a widespread disorder impacting more than one billion individuals globally. Hypertension, a frequent cardiovascular comorbidity associated with OSA, can exacerbate and advance the condition. Recent research has identified a synergistic effect between anemia and OSA concerning the development of hypertension. This study explores the relationship between hemoglobin (Hb) and follow-up and 365-day all-cause mortality in individuals suffering from OSA and hypertension. Data were obtained from the MIMIC-IV database. Kaplan-Meier (KM) analyses and Cox proportional hazards models were utilized to assess associations with outcomes. Restricted cubic spline (RCS) models were selected to assess nonlinear relationships. A total of 6155 patients with first-time hospitalization for OSA and hypertension were included in this study. The KM survival curves demonstrated that the survival rate for the lowest Hb quartile (Q1) was significantly lower than that of the other quartiles. Findings from the multivariable Cox regression analysis revealed that elevated Hb correlates with a significant decrease in mortality risk. The RCS analysis demonstrated an L-shaped nonlinear relationship between Hb and outcome events (P-Nonlinear < 0.05). The relationship between Hb and outcome events remained consistent across all subgroups, further supporting the robustness of the conclusions drawn in this study. Hemoglobin is closely associated with all-cause mortality in patients with OSA and hypertension and can serve as an effective biomarker for risk management and prognostic assessment upon admission. Monitoring Hb in patients with OSA and hypertension and actively correcting anemia when present may improve prognostic survival.
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Registered trials
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