ArticlePhysiological reports2026
Mas-related G protein-coupled receptor type D deficiency promotes tubulointerstitial injury and fibrosis associated with proteinuria in male mice.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury.Acta physiologica (Oxford, England) · 2026Review
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7 authors.
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Abstract
Kidney diseases are non-communicable, progressive diseases with high morbidity and mortality rates worldwide. A key feature of disease progression is the development of tubulointerstitial injury accompanied by proteinuria, a process mediated in part by dysregulation of the Renin-Angiotensin System (RAS). Recently, a novel protective RAS axis consisting of alamandine (Ala) and its receptor, the Mas-related G protein-coupled receptor type D (MrgD), has been identified. While the Ala/MrgD pathway has been implicated in the cardiovascular regulation, its role in renal physiology remains unknown. In this study, we investigated whether basal MrgD deficiency affects the renal structure and function. Male 8-12-week-old C57Bl6/J wild-type (WT) and MrgD knockout (MrgD-KO) mice were used. MrgD-KO exhibited reduced water intake and urine output, increased tubular reabsorption of Na
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