ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
GABA and Glx Distinctively Predict Motor Learning and Retention in Young and Older Adults.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gamma-aminobutyric acid (GABA) and glutamate are fundamental in neural plasticity. Motor learning is predicted by baseline levels of these metabolites and their modulation in the sensorimotor cortex (SM1), but less is known about the metabolic activity in other areas that support learning, such as the dorsolateral prefrontal cortex (DLPFC), as well as the practice-induced metabolic modulation and age-associated differences. We investigated whether: (1) motor learning induces a differential degree of metabolic modulation in the SM1 and DLPFC, (2) learning tasks with higher difficulty levels enhance metabolic modulation as compared with those with lower difficulty levels, (3) metabolic modulation during motor learning is age dependent, and (4) training-induced metabolic modulation may have a differential effect on motor learning and retention. Young (
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