Evidence map›Paper›PMID 41802862›Full record

ArticleeNeuro2026

Numbers of Granule Cells and GABAergic Boutons Are Correlated in Shrunken Sclerotic Hippocampi of Sea Lions with Temporal Lobe Epilepsy.

Megan Wyeth, David D R Krucik, Chloé J Thorbrogger, Cara Field, Paul S Buckmaster

Abstract read
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan WyethDepartment of Comparative Medicine, Stanford University, Palo Alto, California 94304 mwyeth@stanford.edu.ORCID 0000-0003-0680-9591
David D R KrucikDepartment of Comparative Medicine, Stanford University, Palo Alto, California 94304.
Chloé J ThorbroggerDepartment of Comparative Medicine, Stanford University, Palo Alto, California 94304.
Cara FieldThe Marine Mammal Center, Sausalito, California 94965.
Paul S BuckmasterDepartment of Comparative Medicine, Stanford University, Palo Alto, California 94304.ORCID 0000-0003-1627-1799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A possible mechanism of temporal lobe epilepsy is insufficient inhibition of hippocampal dentate granule cells. Precipitating injuries that kill interneurons in the dentate gyrus might result in fewer inhibitory synapses with granule cells. To test this hypothesis, previous studies evaluated numbers or densities of interneurons, γ-amino butyric acid (GABA)ergic boutons, and inhibitory synapses in tissue from human patients with temporal lobe epilepsy and rodent models. However, those studies have limitations. Some of those limitations can be addressed by a large animal model. Sea lions (

Indexed as

Epilepsy, Temporal LobeGABAergic NeuronsHippocampal SclerosisHippocampusNeuronsPresynaptic TerminalsAnimalsCell CountFemaleGlutamate DecarboxylaseInterneuronsMaleSea LionsVesicular Inhibitory Amino Acid Transport ProteinsGlutamate Decarboxylasevesicular GABA transporterVesicular Inhibitory Amino Acid Transport Proteinsdentate gyrusGABAergicgranule cellinterneuronstereologyterminal

Identifiers

PMID41802862
PMCPMC13027691

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.