Evidence map›Paper›PMID 41802860›Full record

ArticlePediatric dermatology

Therapy With Doxycycline and Hydroxychloroquine Enables Surgical Excision of Ulcerated Cutaneous Granulomas in a Patient With Ataxia Telangiectasia.

Luis Murguía-Favela, Sofia Maruschak-Love, Robertson A Harrop, Marie-Anne Brundler, Kyle Kurek, Kevin Fonseca, Michele L Ramien

Abstract readCase Reports
In one paragraph

Article in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luis Murguía-FavelaSection of Hematology and Immunology, Department of Pediatrics, Alberta Children's Hospital and University of Calgary, Calgary, Alberta, Canada.
Sofia Maruschak-LoveFaculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Robertson A HarropSection of Plastic Surgery, Department of Surgery, Alberta Children's Hospital and University of Calgary, Calgary, Alberta, Canada.
Marie-Anne BrundlerDepartment of Pathology and Laboratory, University of Calgary; Pediatric Pathology, Alberta Precision Laboratories, Calgary, Alberta, Canada.
Kyle KurekDepartment of Pathology, University of Utah; Pediatric Pathology, Primary Children's Hospital, Salt Lake City, Utah, USA.
Kevin FonsecaPublic Health Laboratory, Alberta Precision Laboratories, Calgary, AB, Canada & Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Michele L RamienSection of Community Pediatrics, Department of Pediatrics, Alberta Children's Hospital and University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0001-9191-3611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rubella virus vaccine strain can cause granulomas in patients with inborn errors of immunity that may evolve into chronic, recalcitrant ulcers. This report details treatment of ulcerated rubella granulomas in a patient with ataxia telangiectasia with doxycycline and hydroxychloroquine resulting in partial ulcer healing within 4 weeks, which in turn enabled surgical excision. Though this treatment did not cure or clear the rubella virus, that is known to persist in patients with inborn errors of immunity like ataxia telangiectasia, it enabled durable local lesion control of typically chronic, highly morbid ulcers. Histopathology of skin and bone lesions, the latter not previously described in the literature, is included.

Indexed as

Anti-Bacterial AgentsAtaxia TelangiectasiaDoxycyclineGranulomaHydroxychloroquineRubellaSkin UlcerHumansAnti-Bacterial AgentsDoxycyclineHydroxychloroquineataxia telangiectasiagranulomaIEIimmunodeficiencyinborn errors of immunityrubella vaccine

Identifiers

PMID41802860
PMCPMC13422999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.