Evidence map›Paper›PMID 41802805›Full record

ArticleJournal of microbiology (Seoul, Korea)2026

Lacticaseibacillus paracasei KBL382 contributes to the immunomodulation in THP-1 cells.

MinJoong Kim, Min Jung Jo, SungJun Park, Seoung Bum Lee, Sung Jae Jang, Cheonghoon Lee, Woon-Ki Kim, GwangPyo Ko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

MinJoong KimGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Min Jung JoGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
SungJun ParkN-Bio, Seoul National University, Seoul 08826, Republic of Korea.
Seoung Bum LeeGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Sung Jae JangGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Cheonghoon LeeGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Woon-Ki KimGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
GwangPyo KoGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.

Funding

Ministry of EducationMinistry of Science and ICT RS-2022-NR067344National Research Foundation of Korea 2021R1I1A1A01048923
6 · The paper itself

Abstract

Gut microbiome imbalance can induce inflammatory responses via Toll-like receptor 2 (TLR2) signaling pathways. Lactobacillus spp., popularly applied as probiotics in both humans and animals, have come into the spotlight for their strong immunomodulatory effects. We aimed to evaluate the immunomodulatory potential of live or pasteurized Lacticaseibacillus paracasei (L. paracasei) KBL382, isolated from healthy Korean individuals, in an in vitro monocytic THP-1 cell model. Live L. paracasei KBL382 significantly increased TLR2 and MyD88 expressions and induced IRAK1 expression, irrespective of lipopolysaccharide (LPS) stimulation (p < 0.05). Under LPS stimulation, THP-1 cells treated with live L. paracasei KBL382 showed significantly increased interleukin (IL)-6 and IL-10 levels (p < 0.05). Pasteurized L. paracasei exhibited a decrease in IL-12 levels (p < 0.05). Moreover, live L. paracasei KBL382 also markedly elevated A20 and SOCS1 expressions, the critical negative regulators of inflammation, regardless of LPS stimulation (p < 0.05). The expression of IRAK3, another negative regulator of inflammation, was increased in THP-1 cells with live L. paracasei KBL382 under LPS stimulation (p < 0.05). Our findings demonstrate that L. paracasei KBL382 contributes to the immunomodulation in THP-1 cells by coordinating both positive and negative regulatory signaling. L. paracasei KBL382 could be used as a promising probiotic strain for attenuating chronic inflammation through the gut-immune axis mechanisms.

Indexed as

ImmunomodulationLacticaseibacillus paracaseiProbioticsHumansInterleukin-10Interleukin-12Interleukin-1 Receptor-Associated KinasesInterleukin-6LipopolysaccharidesMonocytesMyeloid Differentiation Factor 88Signal TransductionSuppressor of Cytokine Signaling 1 ProteinTHP-1 CellsToll-Like Receptor 2IL10 protein, humanInterleukin-10Interleukin-12Interleukin-1 Receptor-Associated KinasesInterleukin-6IRAK1 protein, humanLipopolysaccharidesMYD88 protein, humanMyeloid Differentiation Factor 88SOCS1 protein, humanSuppressor of Cytokine Signaling 1 ProteinTLR2 protein, humanToll-Like Receptor 2immune responseLacticaseibacillus paracaseinegative regulatory moleculesprobioticToll-like receptor signaling pathway

Identifiers

PMID41802805
PMCPMC13577045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.