Evidence map›Paper›PMID 41802709›Full record

ArticleJournal of pathology and translational medicine2026

3-Dimensional reconstruction reveals frequent intraluminal growth of submucosal veins in surgically resected pT1 colorectal cancers.

Jihyun Park, Mi-Ju Kim, Yeon Wook Kim, Byong-Wook Lee, Junyoung Shin, Jinho Shin, Chan-Gi Pack, Dong-Hoon Yang, Jihun Kim, In Ja Park and 2 more

Abstract read
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In one paragraph

Article in Journal of pathology and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jihyun ParkDepartment of Medical Science, Brain Korea 21 Project, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Mi-Ju KimBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Yeon Wook KimBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Byong-Wook LeeCellular Imaging Core, Convergence Medicine Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Junyoung ShinDepartment of Pathology, National Cancer Center, Goyang, Korea.
Jinho ShinDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Chan-Gi PackDepartment of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Dong-Hoon YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jihun KimDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
In Ja ParkDepartment of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ralph H HrubanDepartment of Pathology, the Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Seung-Mo HongDepartment of Pathology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Funding

Ministry of Science and ICT RS-2023-NR077117National Research Foundation of Korea
6 · The paper itself

Abstract

backgroundAlthough venous invasion (VI) is associated with distant metastasis and observed in >50% of pT2-4 colorectal cancers (CRCs), the role of VI in pT1 CRCs is not well-defined.

methodsThirty-four surgically resected pT1 CRCs were reevaluated for 2-dimensional (2D) VI using hematoxylin and eosin (H&E)-stained slides with additional elastic and desmin immunohistochemical staining (cohort A). Additionally, 27 pT1 CRCs without knowing VI status were selected for 3-dimensional (3D) VI evaluation only (cohort B). All 61 cases (cohorts A and B) were studied in 3D using tissue clearing.

resultsVI was detected more commonly in 3D (17/34, 50.0%) than in 2D H&E slide evaluation (9/34, 26.5%, p = .047). When VI was identified in 3D (27/61, 44.3%), the most common phase was that of intraluminal growth (22/27, 81.5%), followed by intravasation (7/27, 25.9%) and extravasation (5/27, 18.5%). E-cadherin expression was characterized in 3D in foci of VI and varied in each phase of invasion.

conclusionsAll three phases were observed in VI of pT1 CRCs. The extravasation of neoplastic cells from foci of VI in pT1 CRC suggests that VI could be a route of intratumoral spreading in a subset of pT1 CRCs.

Indexed as

CadherinsColonic neoplasmsImaging, Three-dimensionalNeoplasm invasivenessSubmucosaTissue clearingVeins

Identifiers

PMID41802709
PMCPMC13144541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.