Trial reportChest2026
OSA and Acute Coronary Syndrome Severity: The Potential Role of Coronary Collateral Circulation.
Trial report in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01335087 (Impact of Sleep Apnea Syndrome in the Evolution of Acute Coronary Syndrome. Effect of Intervention With Continuous Positive Airway Pressure), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Sleep Apnea Syndrome in the Evolution of Acute Coronary Syndrome. Effect of Intervention With Continuous Positive Airway Pressure (CPAP). A Prospective Randomized Study. ISAACC Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome evidence suggests that OSA may attenuate myocardial injury and reduce infarct severity during acute coronary syndromes (ACSs), potentially through stimulation of coronary collateral circulation (CCC). However, the relationship between OSA and collateral development, and their combined impact on ACS event severity, remains unclear. RESEARCH QUESTION: What is the relationship between OSA and coronary collateral development and what is their combined impact on ACS severity? STUDY DESIGN AND
methodsPost hoc analysis of the Impact of Sleep Apnea in the Evolution of Acute Coronary Syndrome: Effect on Intervention With CPAP (ISAACC) trial, including patients with first-time ACS with CCC assessment using the Cohen-Rentrop scale (CRS), where a score of ≥ 2 (CRS grade 2 or 3) indicated well-developed collaterals. OSA was diagnosed via respiratory polygraphy performed within 24 to 72 hours of hospitalization. Associations between OSA and CRS grade 2 or 3 were evaluated using adjusted logistic regression. Peak creatine kinase (CK), peak cardiac troponin I (cTnI), and left ventricular ejection fraction (LVEF) were analyzed as ACS severity markers.
resultsOf 185 participants included, 79.5% had OSA. Participants were mainly middle-aged male individuals and demonstrated a high comorbidity burden. OSA was associated with greater odds of well-developed collaterals with an adjusted OR of 2.84 (95% CI, 1.24-7.19; P = .019), with a dose-response increase across OSA severity categories. Among patients with OSA, the presence of robust collaterals was associated with significantly lower peak CK and cTnI levels during the ACS episode, but not with improved LVEF.
interpretationOur research shows that in patients with first-time ACS, OSA was associated with a higher prevalence of well-developed coronary collaterals. Among patients with OSA, robust collateralization was associated with less myocardial injury during ACS, supporting the hypothesis that OSA may promote adaptive vascular remodeling, which warrants further mechanistic investigation. CLINICAL
trial registrationClinicalTrials.gov; No.: NCT01335087; URL: www. CLINICALTRIALS: gov.
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