Evidence map›Paper›PMID 41802386›Full record

ArticlePlacenta2026

Effect of combined HIV and Substance use during pregnancy on placental efficiency.

Julia Glace, Annie Johnson, Noor Chadha, Sorraya Jaiprasert, Elizabeth Taglauer, Elijah Paintsil, Elisha M Wachman, Naima T Joseph

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia GlaceBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Annie JohnsonBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Noor ChadhaDepartment of Obstetrics & Gynecology, Boston Medical Center, Boston, MA, USA.
Sorraya JaiprasertDepartment of Pediatrics, Boston Medical Center, Boston, MA, USA.
Elizabeth TaglauerBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
Elijah PaintsilBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
Elisha M WachmanBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
Naima T JosephBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Obstetrics & Gynecology, Boston Medical Center, Boston, MA, USA. Electronic address: Naima.Joseph@bmc.org.

Funding

Association of maternal, fetal and placental biomarkers with neonatal neuroimaging and development following in-utero opioid exposureR01HD113143 · NICHD · BOSTON MEDICAL CENTER · PI Elisha Wachman · 2023 to 2026
$3.4M
Pediatric HIV Disclosure Intervention and Benefits Study-(PH-DIBS)R01HD103512 · NICHD · YALE UNIVERSITY · PI PAINTSIL, ELIJAH, REYNOLDS, NANCY R · 2020 to 2024
$3.4M
NICHD NIH HHS R01 HD103512NICHD NIH HHS R01 HD113143
6 · The paper itself

Abstract

We examined the impact of combined HIV exposure and substance use disorder (SUD) on perinatal outcomes and placental pathology in a retrospective cohort of 268 pregnancies (2015-2024). Participants included HIV-only, SUD-only, combined HIV/SUD, and unexposed groups. The primary outcome was placental efficiency score, analyzed using multivariate regression. Nicotine (52.6%) and medications for opioid use disorder (82.8%) were the predominant exposures. The concurrent HIV/SUD group demonstrated the lowest placental efficiency, even after adjusting for hypertensive disorders [mean difference -1.7 (95% CI -3.2, -0.3)]. Combined HIV and SUD exposure may impair placental function and contribute to adverse perinatal outcomes, warranting further investigation.

Indexed as

HIV InfectionsPlacentaPregnancy ComplicationsPregnancy Complications, InfectiousSubstance-Related DisordersAdultFemaleHumansPregnancyPregnancy OutcomeRetrospective StudiesAntiretroviral therapyHIVMedication for opioid use disorderPlacentaPregnancySubstance use disorder

Identifiers

PMID41802386
PMCPMC13007734

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.