Evidence map›Paper›PMID 41802309›Full record

ArticleAnnals of coloproctology2026

Interim analysis of short-term outcomes between robotic and laparoscopic surgery for colon cancer: results from the ESSIMIC trial.

Marco Milone, Sara Vertaldi, Pietro Anoldo, Simona Borin, Graziano Ceccarelli, Anna D'Amore, Maurizio Degiuli, Paolo Delrio, Uberto Romario Fumagalli, Mario Guerrieri and 11 more

Registry-linked trialAbstract read
In one paragraph

Article in Annals of coloproctology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02871960 (Evaluation of Surgical Stress and Immune Response After Minimally Invasive Colorectal Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02871960 naunknown statusnot on this map

Evaluation of Surgical Stress and Immune Response After Minimally Invasive Colorectal Surgery (ESSIMIC)

TypeinterventionalSponsorFederico II UniversityRan2016 to 2020Enrolled170ConditionsSurgical Stress and Immune FunctionArmsRobotic and Laparoscopic Colectomy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marco MiloneDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Sara VertaldiDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Pietro AnoldoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Simona BorinDivision of Digestive Surgery, European Institute of Oncology IRCCS, Milan, Italy.
Graziano CeccarelliDepartment of General Surgery, San Giovanni Battista Hospital, Perugia, Italy.
Anna D'AmoreDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Maurizio DegiuliDepartment of Oncology, San Luigi University Hospital, University of Turin, Turin, Italy.
Paolo DelrioDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione Pascale IRCCS, Naples, Italy.
Uberto Romario FumagalliDivision of Digestive Surgery, European Institute of Oncology IRCCS, Milan, Italy.
Mario GuerrieriDepartment of General and Emergency Surgery, Polytechnic University of Marche, Ancona, Italy.
Michele ManigrassoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Monica OrtenziDepartment of General and Emergency Surgery, Polytechnic University of Marche, Ancona, Italy.
Ugo PaceDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione Pascale IRCCS, Naples, Italy.
Felice PirozziGeneral Surgery Unit, A. Cardarelli Hospital, Naples, Italy.
Lucia PucaDepartment of Oncology, San Luigi University Hospital, University of Turin, Turin, Italy.
Wanda PetzDivision of Digestive Surgery, European Institute of Oncology IRCCS, Milan, Italy.
Rossella ReddavidDepartment of Oncology, San Luigi University Hospital, University of Turin, Turin, Italy.
Daniela RegaDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione Pascale IRCCS, Naples, Italy.
Fabio RondelliDepartment of General Surgery, San Giovanni Battista Hospital, Perugia, Italy.
Antonio SciutoGeneral Surgery Unit, A. Cardarelli Hospital, Naples, Italy.
Giovanni Domenico De PalmaDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to determine whether the benefits of robotic surgery can be applied to the treatment of colon cancer by evaluating short-term outcomes of robotic versus laparoscopic colonic resection.

methodsThis interim analysis of an interventional multicenter randomized trial was conducted to compare outcomes of robotic and laparoscopic colorectal surgery performed between January 2017 and December 2019. The study specifically assessed short-term outcomes in patients undergoing laparoscopic or robotic right or left colectomy for cancer. In addition, all short-term outcomes were evaluated in separate subgroups of right and left colonic resections through prespecified subgroup analyses.

resultsA total of 323 patients were analyzed, of whom 142 underwent robotic-assisted surgery and 181 underwent laparoscopic surgery. Overall, 109 complications (33.7%) occurred in the short-term period, 41 (28.9%) in the robotic group and 68 (37.6%) in the laparoscopic group, with no differences between groups in intraoperative or postoperative complications. However, grade III complications were significantly more frequent in the laparoscopic group, with 17 cases (9.4%) compared to 5 cases (3.5%) in the robotic group. Oncological radicality was similar between groups. Functional recovery after surgery was superior in the robotic group, as reflected by a shorter time to mobilization (17.5±10.2 hours vs. 21.1±11.5 hours). In the right colectomy subgroup, rates of grade III complications (1.9% vs. 11.7%) and lymph nodes retrieved (20.3±10.3 vs. 20.2±6.4) favored robotic surgery. In the left colon cancer subgroup, functional recovery was also improved with robotic surgery (44.3±22.2 hours vs. 61.1±31.1 hours, as measured by the composite recovery outcome).

conclusionRobotic surgery is associated with fewer severe complications and improved postoperative recovery following colonic resections. Trial registration: ClinicalTrials.gov identifier: NCT02871960.

Indexed as

Colonic neoplasmsColon surgeryLaparoscopyRobotic surgeryShort-term outcomes

Identifiers

PMID41802309
PMCPMC12971168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.