ReviewBJS open2025
Diagnosis and treatment of primary soft tissue sarcomas: comprehensive review.
Review in BJS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Local Recurrence and Metastasis Define Distinct Recurrence Phenotypes in Soft Tissue Sarcoma.Cancers · 2026Article
- Case Report: Role of MRI, CT, and 18F-FDG PET/CT in staging and response assessment of pediatric synovial sarcoma.Frontiers in nuclear medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoft tissue sarcomas (STSs) comprise a group of rare malignancies with anatomic- and histologic-specific patterns of local and distant recurrence. Due to their rarity and histology-specific tumour behaviour, their natural history and the efficacy of various interventions may be challenging to assess. The aim of this review is thus to provide a comprehensive overview of diagnostic and treatment options for localized extremity and retroperitoneal STSs.
methodsA literature search was conducted to identify articles related to the diagnosis and management of localized extremity and retroperitoneal STSs. English-language articles published until June 2025 were identified using Medical Subject Heading terms on PubMed. Results were reported using a narrative approach. Topics highlighted in this review include diagnosis, institutional volumes, treatment options, and multimodal management of STSs based on location.
resultsAccurate diagnosis of STS relies on carefully planned preoperative biopsies and in selected cases is supplemented by advanced molecular diagnostic tools. Surgery remains the cornerstone of curative-intent treatment for localized STSs; however, resectability criteria for retroperitoneal STSs vary by institution. Institutional case volumes are prognostic of outcome, with 10-20 retroperitoneal sarcoma cases per year considered by experts to be indicative of high-volume sarcoma centres. The role of adjunctive therapies, including chemotherapy, radiation, and/or other locoregional treatments, is dictated by histological and molecular characteristics associated with local and distant recurrence rates.
conclusionThe management of localized STSs is multidisciplinary in nature, requiring consideration of tumour and patient characteristics, and treatment factors. The rarity of STSs and the variable biological behaviour of the various histologic subtypes have impacted research in this field. Ongoing international collaborations and innovative study designs are essential for advancing the understanding of tumour behaviour and in optimizing treatment approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.