Evidence map›Paper›PMID 41802229›Full record

ArticleAnnals of medicine2026

Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates.

Tongyangzi Zhang, Heng Wu, Haodong Bai, Jiguang Wu, Lili Zhang, Rongrong Li, Yiqing Zhu, Bingxian Sha, Jiaying Yuan, Yaxing Zhou and 2 more

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Tongyangzi ZhangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-4375-0499
Heng WuDepartment of Psychosomatic Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Haodong BaiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiguang WuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Lili ZhangDepartment of Dermatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Rongrong LiDepartment of Dermatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiqing ZhuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Bingxian ShaDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiaying YuanDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yaxing ZhouDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-8713-5332
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-1054-017X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCough hypersensitivity syndrome (CHS) is a characteristic of patients with chronic cough (CC). Sensitive skin syndrome (SSS), which is characterised by cutaneous pain and pruritus, may share neural hypersensitivity mechanisms with CHS. This study aimed to determine the co-morbidities, clinical profiles, and psychosomatic correlates in CC patients.

methodsTwo hundred CC patients were enrolled in this prospective cohort study. SSS was diagnosed according to established guidelines, which required the presence of subjective symptoms induced by minimal stimuli with at least one of the following positive criteria: Sensitive Scale-10 score > 13; Sensitive Scale-14 score > 18; lactic acid sting test score ≥ 3; or capsaicin test score ≥ 3. Assessments included cough severity, Visual Analogue Scale (VAS), capsaicin cough sensitivity, cough symptom score, Leicester cough questionnaire (LCQ), and psychological evaluations.

resultsAmong CC patients, 44.5% (89/200) had SSS with a higher prevalence in refractory/unexplained CC (RU-CC) patients compared to non-RU-CC patients (63.24% vs. 34.85%;

conclusionSSS was identified in a clinically relevant subset of CC patients (especially those with RU-CC) and correlated with neural hypersensitivity and psychological distress. Early recognition of SSS in patients with CC and the early introduction of neuromodulators may offer greater therapeutic benefits and improve patient outcomes.

Indexed as

Chronic CoughCoughHypersensitivityPsychophysiologic DisordersAdultAgedCapsaicinComorbidityFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesPruritusSeverity of Illness IndexCapsaicinChronic coughneuromodulatorpsychosomatic co-morbidityrefractory chronic coughsensitive skin syndrome

Identifiers

PMID41802229
PMCPMC12973777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.