Evidence map›Paper›PMID 41802160›Full record

ArticleEuropean heart journal. Acute cardiovascular care2026

The haemodynamic envelope, a novel aviation-inspired safety framework for personalized monitoring in cardiogenic shock.

Christiaan Lucas Meuwese, Joris Anthonius Melkert, Jacob Eifer Møller

Abstract read
In one paragraph

Article in European heart journal. Acute cardiovascular care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christiaan Lucas MeuweseDepartment of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, the Netherlands.ORCID 0000-0002-1901-1653
Joris Anthonius MelkertFaculty of Aerospace Engineering, Delft University of Technology, Delft, the Netherlands.
Jacob Eifer MøllerDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mortality in severe forms of cardiogenic shock remains above 50%, despite substantial advances in mechanical circulatory support strategies that have enabled clinicians to manage levels of patient complexity once thought unattainable. A key obstacle to effectively implementing and individualizing these sophisticated treatments lies in the continued reliance on outdated safety monitoring strategies that apply uniform cut-off values to a limited set of clinical variables. Such approaches fail to account for the dynamic and patient-specific nature of 'safe' haemodynamics. To overcome this, we propose an aviation-inspired safety framework, referred to by 'the haemodynamic envelope', designed to continuously and automatically compute patient- and time-specific thresholds across nine interrelated dimensions. This framework defines a dynamic safety window analogous to the systems that transformed flight safety.

Indexed as

AviationHemodynamicsPrecision MedicineShock, CardiogenicHumansAcute heart failureFlight envelopeFlight safetyhaemodynamic envelopePersonalized therapy

Identifiers

PMID41802160
PMCPMC13624657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.