Evidence map›Paper›PMID 41802094›Full record

ArticleActa haematologica2026

BEAC Induction Regimen and Prior Thoracic Radiotherapy Increases the Risk of ASCT-Associated Pneumonitis.

Elina Kaprio, Anna Jokimäki, Hanne Kuitunen, Joel Kontiainen, Tuomas Selander, Taina Turpeenniemi-Hujanen, Outi Kuittinen

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Article in Acta haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Elina KaprioInstitute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland, elina.kaprio@fimnet.fi.
Anna JokimäkiInstitute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland.
Hanne KuitunenOulu University Hospital, Medical Research Center and Cancer Centre, Oulu University Hospital, Oulu, Finland.
Joel KontiainenDepartment of Oncology, Tampere University Hospital and Tampere University, Tampere, Finland.
Tuomas SelanderScience Service Center, Kuopio University Hospital, Kuopio, Finland.
Taina Turpeenniemi-HujanenOulu University Hospital, Medical Research Center and Cancer Centre, Oulu University Hospital, Oulu, Finland.
Outi KuittinenInstitute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHigh-dose chemotherapy (HDT) followed by autologous stem cell transplant (ASCT) has been standard of care in the treatment of relapsed and refractory lymphoma. Some severe toxicities are associated with this treatment modality. Pulmonary toxicity is one of these significant adverse effects and a potential cause of treatment-related mortality.

methodsIn this retrospective study, we report the incidence, risk factors, and outcome of treatment-induced pneumonitis in 286 lymphoma patients receiving HDT followed by ASCT.

resultsThe cumulative incidence of treatment-induced pneumonitis was 4.6% and occurred in 11/286 patients. Three months incidence rate was 2.6%. Most of the patients diagnosed with treatment-induced pneumonitis had received BEAC as HDT regimen. The risk of treatment-induced pneumonitis was higher if HDT-ASCT was given in later treatment lines. Also, a prior thoracic radiotherapy as part of first-line treatment was associated with higher risk for pneumonitis after HDT-ASCT. In 2 patients, the pneumonitis did not respond to high-dose steroid treatment.

conclusionThis study provides new information about the incidence of pneumonitis associated with HDT-ASCT and its risk factors, which might be useful to take into consideration during and after treatment with HDT-ASCT.

Indexed as

Autologous stem cell transplantHigh-dose chemotherapyLymphomaTreatment-induced pneumonitis

Identifiers

PMID41802094
PMCPMC13148807

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