Evidence map›Paper›PMID 41802055›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress.

Xue-Ke Yang, Yu-Long Shi, Ming Li, Tong-Xia Li, Jian Yang, Jie Lei, Chi Cui, Xiang Peng, Hong-Chu Zha, Gan-Gan Luo and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xue-Ke YangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Yu-Long ShiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Ming LiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Tong-Xia LiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Jian YangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Jie LeiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Chi CuiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Xiang PengDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Hong-Chu ZhaHubei Provincial Clinical Research Center for Alzheimer's Disease, Brain Science and Advanced Technology Institute, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Gan-Gan LuoDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Yi-Bo YaoDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Si-Tong ChenDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Jun-Song DuDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Hui-Juan WangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Shi-Qi XuHubei Provincial Clinical Research Center for Alzheimer's Disease, Brain Science and Advanced Technology Institute, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.
Pei ZhangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.ORCID 0000-0003-0608-5677
Bo TianHubei Provincial Clinical Research Center for Alzheimer's Disease, Brain Science and Advanced Technology Institute, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.

Funding

MOST | National Natural Science Foundation of China (NSFC) 31871073MOST | National Natural Science Foundation of China (NSFC) 32171023MOST | National Natural Science Foundation of China (NSFC) 32271036MOST | National Natural Science Foundation of China (NSFC) 32471034MOST | National Natural Science Foundation of China (NSFC) 32571176
6 · The paper itself

Abstract

Personal experiences are encoded and stored in memory engram cells and are crucial for social preference dynamics in future social contexts, yet the neural circuit mechanisms involved are still poorly understood. Here, we develop a mouse model that combines self-experienced single social defeat stress with vicarious social defeat stress, demonstrating a social preference with defeat stress-experienced cagemate and social avoidance toward an aggressor. Basolateral amygdala engram cells (BLA

Indexed as

Basolateral Nuclear ComplexSocial BehaviorStress, PsychologicalAnimalsBehavior, AnimalGyrus CinguliHippocampusMaleMiceMice, Inbred C57BLSocial Defeatbasolateral amygdalaengram cellsneural circuitsself-experiencesocial preference dynamics

Identifiers

PMID41802055
PMCPMC12994165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.