Evidence map›Paper›PMID 41802049›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Adhesion forces between macrophages and cancer cells promote early tumor development.

Jovan Nikolic, Joseph Ackermann, Ines Marin, Sarah Taheraly, Morgane Mabire, François-Xavier Gobert, Mathieu Maurin, Apolline de Testas de Folmont, Ouardia Aït-Mohamed, Edison Gerena and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jovan Nikolic *Institut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.ORCID 0000-0003-4119-7009
Joseph Ackermann *Laboratoire de Physique de l'Ecole normale supérieure, Ecole Normale Supérieure, Université Paris Sciences et Lettres, Centre National de la Recherche Scientifique, Sorbonne Université, Université Paris Cité, F-75005 Paris, France.
Ines MarinGenentech, Department of Immunology and Ophthalmology. South San Francisco, CA 94080.
Sarah TaheralyInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Morgane MabireInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
François-Xavier GobertInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Mathieu MaurinInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Apolline de Testas de FolmontInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.ORCID 0009-0009-6460-9046
Ouardia Aït-MohamedInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Edison GerenaSorbonne Université, Centre National de la Recherche Scientifique UMR7222, Institut des Systèmes Intelligents et de Robotique, 75005 Paris, France.
Sophie GoyardInstitut Pasteur, Université de Paris Cité, Institut National de la Santé et de la recherche Médicale-U1224, Cell Biology of Lymphocytes, F-75015 Paris, France.ORCID 0000-0002-8937-2796
Jérémy MespleInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Hélène SalmonInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.
Thierry RoseInstitut Pasteur, Université de Paris Cité, Institut National de la Santé et de la recherche Médicale-U1224, Cell Biology of Lymphocytes, F-75015 Paris, France.
Christine MoussionGenentech, Department of Immunology and Ophthalmology. South San Francisco, CA 94080.
Martine Ben AmarLaboratoire de Physique de l'Ecole normale supérieure, Ecole Normale Supérieure, Université Paris Sciences et Lettres, Centre National de la Recherche Scientifique, Sorbonne Université, Université Paris Cité, F-75005 Paris, France.
Jean-François JoannyInstitut Curie Physics of Cells and Cancer/Collège de France Chair Soft Matter and Biophysics, Paris Cedex 05, France.ORCID 0000-0001-6966-3222
Philippe BenarochInstitut Curie, Paris Sciences & Lettres University, Institut National de la Santé et de la recherche Médicale U932, Immunity and Cancer, 75005 Paris, France.ORCID 0000-0002-2655-0129

Funding

Agence nationale de la recherche ANR OPTOBOT ANR-2021 CE33-0003-03Agence nationale de la recherche EpiMorph ANR-18-CE13-0008Agence Nationale de la Recherche MecaTiss ANR-17-CE30-0007Alliance Nationale pour les Sciences de la Vie et de la Santé (AVIESAN) ITMO MCMPAlliance Nationale pour les Sciences de la Vie et de la Santé (AVIESAN) ITMO PCSIChercher et trouver CIC IGR-Curie 1428Laboratoire d'Excellence (Labex) DCBIOL ANR-10-IDEX-0001-02 PSL and ANR-11-LABX-0043Region Ile-de-France DIM Elicit equipmentUniversité de Recherche Paris Sciences et Lettres (PSL) PSL-Maturation-Qlife
6 · The paper itself

Abstract

Biochemical mechanisms of macrophage-driven tumor promotion are well documented, but the contribution of physical forces to early tumor development remains poorly understood. Here, we combine experimental analyses with physical modeling to investigate these forces in Kras

Indexed as

Lung NeoplasmsMacrophagesAnimalsCD11c AntigenCell AdhesionCell Line, TumorCell ProliferationHumansMiceMice, KnockoutProto-Oncogene Proteins p21(ras)Spheroids, CellularTumor Suppressor Protein p53CD11c AntigenProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53macrophagephysical forcestumor

Identifiers

PMID41802049
PMCPMC12994214

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.