Evidence map›Paper›PMID 41802048›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Bacterial reporter-paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense.

Jessica B von Pein, Stacey B Andersen, Jon Xu, Minh-Duy Phan, Emma K Dalton, Michael Koczerka, Claudia J Stocks, James E B Curson, Zoe Vandeleur, Nicholas D Condon and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jessica B von PeinInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Stacey B AndersenGenome Innovation Hub, The University of Queensland, Brisbane, QLD 4072, Australia.
Jon XuGenome Innovation Hub, The University of Queensland, Brisbane, QLD 4072, Australia.
Minh-Duy PhanInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-3426-1044
Emma K DaltonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0009-0006-5668-0668
Michael KoczerkaInfectiologie et Santé Publique, Institut national de recherche pour l'agriculture, l'alimentation et l'environnement, Université de Tours, Nouzilly 37380, France.
Claudia J StocksInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-6120-2851
James E B CursonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-4672-3357
Zoe VandeleurInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Nicholas D CondonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-1833-1129
Steven J HancockInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-7203-2640
Christian M NefzgerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Nathan J PalpantInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-9334-8107
Divya RamnathInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-1935-9043
Ronan KapetanovicInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-2908-1014
Mark A SchembriInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-4863-9260
Matthew J SweetInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-0406-8139

Funding

Chan Zuckerberg Initiative (CZI) 2023-329684DHAC | National Health and Medical Research Council (NHMRC) APP1144967DHAC | National Health and Medical Research Council (NHMRC) APP1194406
6 · The paper itself

Abstract

Mechanisms by which macrophages deploy antibacterial zinc toxicity are poorly understood. To gain insight into this antimicrobial pathway, we developed bacterial reporter-paired single-cell RNA sequencing of human monocyte-derived macrophages (HMDM) infected with an

Indexed as

Escherichia coliMacrophagesZincAnti-Bacterial AgentsCation Transport ProteinsEscherichia coli InfectionsHumansSingle-Cell Gene Expression AnalysisAnti-Bacterial AgentsCation Transport ProteinsZincE. colimacrophagesingle-cell RNA sequencingSLC30A4/ZNT4zinc toxicity

Identifiers

PMID41802048
PMCPMC12993976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.