Evidence map›Paper›PMID 41801988›Full record

ArticleHaemophilia : the official journal of the World Federation of Hemophilia

Haemophilia Care in India: A Multicentre Cross-Sectional Analysis From the World Bleeding Disorders Registry Benchmarking Across Global Gross National Income Strata.

Nita Radhakrishnan, M Joseph John, Emily Ayoub, Ticiana Pereira, Anupam Dutta, Sreejith Govindan, Neeraj Sidharthan, Chepsy C Philip, Archit Pandharipande, Damanpreet Singh and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nita RadhakrishnanDepartment of Pediatric Hematology Oncology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-7941-5641
M Joseph JohnDepartment of Clinical Haematology, Haemato-Oncology and Bone Marrow (Stem Cell) Transplantation, Christian Medical College, Ludhiana, Punjab, India.ORCID https://orcid.org/0000-0003-0820-7332
Emily AyoubWorld Federation of Hemophilia, Quebec, Canada.ORCID https://orcid.org/0000-0002-9461-5123
Ticiana PereiraWorld Federation of Hemophilia, Quebec, Canada.
Anupam DuttaDepartment of Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, India.ORCID https://orcid.org/0000-0001-9520-5196
Sreejith GovindanDepartment of Basic Medical Sciences, and Hemophilia Society, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0002-2984-5053
Neeraj SidharthanDepartment of Clinical Hematology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Chepsy C PhilipDepartment of Clinical Hematology, Believers Church Medical College Hospital, Tiruvalla, Kerala, India.
Archit PandharipandeDepartment of Pediatric Hematology Oncology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India.ORCID https://orcid.org/0000-0003-2531-4017
Damanpreet SinghDepartment of Clinical Haematology, Haemato-Oncology and Bone Marrow (Stem Cell) Transplantation, Christian Medical College, Ludhiana, Punjab, India.ORCID https://orcid.org/0009-0005-6760-6618
Harshal KaleRegional Program Manager, South Asia and East Asia, World Federation of Hemophilia, New Delhi, India.ORCID https://orcid.org/0009-0008-6817-4812
Donna CoffinWorld Federation of Hemophilia, Quebec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHaemophilia care varies across economic settings, influencing diagnosis, treatment and outcomes. The World Bleeding Disorders Registry (WBDR) enables standardized, patient-level global benchmarking. We present the first multicentre analysis of Indian persons with haemophilia (PwH) in the WBDR, enabling robust benchmarking against regional and income-stratified global cohorts.

methodsThis cross-sectional study analysed de-identified WBDR data from six haemophilia treatment centres in India across geographic areas. Standardized demographic, clinical, and treatment indicators were benchmarked against South-East Asia (SEA), income-stratified global WBDR cohorts, and World Federation of Hemophilia Annual Global Survey (WFH AGS) 2023 data, focusing on diagnosis, severity, treatment, functional status, inhibitor status and employment.

resultsAmong 1,780 PwH (86% haemophilia A), 77% had severe disease. Median age was 20 years (IQR 11-31), significantly younger than global WBDR and AGS cohorts (p < 0.001). Median age at diagnosis for severe haemophilia was 60 months (IQR 12180), markedly later than in upper-middle- and high-income countries (p < 10

conclusionsIndian WBDR data underscore the value of registry participation for meaningful benchmarking of haemophilia care, highlighting progress in diagnosis and employment outcomes alongside clear opportunities to expand treatment coverage and improve clinical outcomes.

Indexed as

BenchmarkingHemophilia AIncomeRegistriesAdolescentAdultChildChild, PreschoolCross-Sectional StudiesFemaleHumansIndiaInfantMaleYoung AdultGross national income (GNI)HaemophiliaIndiaProphylaxisReal‐world dataWorld Bleeding Disorders Registry (WBDR)

Identifiers

PMID41801988
PMCPMC13378630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.