ArticlePloS one2026
Shining light on vitamin C deficiency and scurvy in Canada: A scoping review protocol of risk profiles, health outcomes, and interventions.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scurvy, resulting from vitamin C deficiency, is linked to serious health outcomes, including impaired collagen synthesis, anemia, and delayed wound healing. Once considered largely eradicated in high-income countries, scurvy has re-emerged among specific Canadian populations, driven by factors such as inadequate dietary intake, socioeconomic disparities, and limited access to nutritious foods. Despite growing awareness, evidence regarding its prevalence, risk factors, and public health responses in Canada remains sparse and fragmented. To address this knowledge gap, this study protocol outlines a scoping review designed to: (a) assess the prevalence and incidence of scurvy and vitamin C deficiency in Canada; (b) identify at-risk populations and contributing factors; (c) describe associated health outcomes; and (d) map existing nutritional interventions and public health strategies for prevention and management. Our review will follow the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis (Chapter 11: Scoping review) and the Arksey and O'Malley methodological framework. Keywords will be identified and used to develop search strings used for a comprehensive search of various databases. The review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR) guidelines. Our study selection process will systematically screen titles/abstracts and full texts of potentially relevant articles to ensure a comprehensive analysis through thematic analysis. We will implement a clearly defined extraction process to gather the most pertinent articles, maximizing the quality and impact of our research. Ethical approval is not required because this study will review publicly available data and will not involve human participants. Our scoping review will synthesize evidence on scurvy and vitamin C deficiency in Canada, identifying knowledge gaps, contributing factors such as food insecurity, and vulnerable populations. Findings will inform research priorities, guide public health policies, and support targeted interventions to prevent deficiency and enhance nutritional health for Canadians.
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Registered trials
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