Evidence map›Paper›PMID 41801791›Full record

ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2026

An Intuitive, Bidirectional, and Adaptive Functional Electrical Stimulation System for Hand Rehabilitation.

Marshall A Trout, Clay T Stanley, Kristen M Saad, Abigail T Harrison, Mingxi Liu, Jacob A George

Abstract read
In one paragraph

Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marshall A Trout
Clay T Stanley
Kristen M Saad
Abigail T Harrison
Mingxi Liu
Jacob A George

Funding

Patient-centered rehabilitation and dexterous assistive devices for stroke patients using bionic exoskeletons controlled by non-invasive electromyographyDP5OD029571 · OD · UNIVERSITY OF UTAH · PI GEORGE, JACOB ANTHONY · 2020 to 2024
$2.1M
NIH HHS DP5 OD029571
6 · The paper itself

Abstract

After a neuromotor injury, such as a stroke or spinal cord injury, patients are faced with decreased independence and quality of life due to limited hand function. Functional electrical stimulation (FES) therapy can improve patients' recovery. However, this technology is underutilized in clinics due to complex and long setup times, and there is a distinct lack of commercially available FES systems for hand therapy. In this work, we present a closed-loop, bidirectional FES system specifically designed for grasping rehabilitation. The proposed FES system leverages a first-order, adapting local model of muscle activation dynamics to control grip force by modulating the FES amplitude. We demonstrate with 12 healthy participants that the adaptive controller provides more accurate control than an autotuned PID controller. We also validate that the FES system works with a C5 spinal cord injury (SCI) participant exhibiting a typical upper motor neuron pattern of spasticity. Each participant also completed a longer-duration fatiguing experiment, and we observed that not only does the controller adapt to accurately control contractions as the activated muscles fatigue, but the model parameters are strongly correlated with fatigue and could be used to measure fatigue in real time. Finally, we show that a previously untrained user can set up the FES system in under 5 minutes. These results demonstrate the benefits of using adaptive models for FES control and can be used as a guide to design effective, translatable FES systems.

Indexed as

Electric Stimulation TherapyHandAdaptive AlgorithmsAdultAlgorithmsEquipment DesignFemaleHand StrengthHumansMaleMiddle AgedMuscle ContractionMuscle FatigueMuscle, SkeletalReproducibility of ResultsSpinal Cord Injuries

Identifiers

PMID41801791
PMCPMC13208101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.