Evidence map›Paper›PMID 41801750›Full record

ArticleThyroid : official journal of the American Thyroid Association2026

Thyroid Hormone Synthesis Without Thyroglobulin.

Crystal Young, Xiaohan Zhang, Aaron P Kellogg, Tatiana L Fonseca, Kevin Pena, Alisa Beyzin, Xiao-Hui Liao, Annunziata G Cicatiello, Hao Zhang, Antonio C Bianco and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Crystal YoungDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Xiaohan ZhangDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Aaron P KelloggDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Tatiana L FonsecaDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Kevin PenaDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Alisa BeyzinDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Xiao-Hui LiaoDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Annunziata G CicatielloDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Hao ZhangDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Antonio C BiancoDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Samuel RefetoffDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Peter ArvanDivision of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4007-8799

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
Endoplasmic Reticulum stress and thyroid cell deathR01DK132017 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN · 2022 to 2026
$1.9M
Adaptive Response(s) to Complete Thyroglobulin Gene KnockoutF30DK139717 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kathy Crystal Young · 2024 to 2026
$147k
NEI NIH HHS P30 EY007003NIDDK NIH HHS F30 DK139717NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R01 DK132017NIH HHS F30DK139717NIH HHS P30DK020572NIH HHS P30EY007003NIH HHS R01DK15070
6 · The paper itself

Abstract

backgroundHeterozygosity of genetically encoded misfolded mutant thyroglobulin (TG, the thyroid hormone protein precursor) occurs with a frequency estimated at 1-in-217 people worldwide, resulting in subclinical hypothyroidism that largely escapes medical detection. However, patients carrying biallelic

methodsWe recently engineered mice with homozygous

resultsWe found that, concomitant with goiter growth, animals completely lacking TG (like patients or animals with biallelic

conclusionsOur data suggest that in biallelic TG mutation, thyroid stimulating hormone (TSH)-driven iodination underlies inefficient T4 formation derived from the iodoproteome of dead thyrocytes. In the presence of homozygous mutant TG or in the complete absence of TG, normalizing circulating T4 requires massive goiter growth to generate sufficient cells to sustain this inefficient hormonogenesis mechanism.

Indexed as

GoiterThyroglobulinThyroid GlandThyroid HormonesThyroxineTriiodothyronineAnimalsHumansHypothyroidismMiceMice, KnockoutThyroid Epithelial CellsThyroglobulinThyroid HormonesThyroxineTriiodothyronineapoptosisgoiteriodinationthyrocytethyroxinetriiodothyronine

Identifiers

PMID41801750
PMCPMC13184668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.