Evidence map›Paper›PMID 41801672›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026

Schisandrin A alleviates UVB-induced photoaging via AMPK/Nrf2-mediated antioxidant and autophagy pathways.

Shuangling Wang, Kexin Liu, Meihao Zhang, Shiqi Wang, Zhengyi Li, Wenyue Zhuang

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Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuangling WangDepartment of Molecular Biology Test Technique, College of Medical Technology, Beihua University, Jilin, 132000, China.
Kexin LiuDepartment of Molecular Biology Test Technique, College of Medical Technology, Beihua University, Jilin, 132000, China.
Meihao ZhangDepartment of Molecular Biology Test Technique, College of Medical Technology, Beihua University, Jilin, 132000, China.
Shiqi WangDepartment of Molecular Biology Test Technique, College of Medical Technology, Beihua University, Jilin, 132000, China.
Zhengyi LiDepartment of Clinical Examination Basis, Laboratory Academy, Jilin Medical University, Jilin, 132000, China. 761322695@qq.com.
Wenyue ZhuangDepartment of Diagnostics, Hwamei College of Life and Health Sciences, Zhejiang Wanli University, Ningbo, 315100, China. wenyuezhuang@163.com.

Funding

Jilin Province Scientific and Technology Development Project YDZJ202201ZYTS637
6 · The paper itself

Abstract

Skin photoaging, primarily induced by chronic UVB exposure, lacks effective therapeutic options. Schisandrin A (Sch A), a bioactive compound from Schisandra chinensis, has been traditionally used in East Asian medicine for its anti-inflammatory and antioxidant properties. However, the precise mechanisms by which Sch A exerts photoprotective effects against UVB-induced damage remain unclear, warranting further mechanistic exploration. This study aimed to explore the protective effects of Sch A against UVB-induced damage in HaCaT keratinocytes and ICR mice. Sch A improved cell viability, reduced senescence and apoptosis, and enhanced antioxidant defenses by increasing SOD activity and GSH levels while reducing MDA accumulation in mice. Histological analysis showed that Sch A decreased epidermal thickness and preserved dermal collagen. Molecular assays revealed that Sch A activated AMPK and Nrf2 signaling, promoted autophagy, reduced oxidative stress, and inhibited MMP expression. These findings suggest that Sch A alleviates photoaging by modulating oxidative stress, apoptosis, and autophagy via the AMPK/Nrf2 pathways, offering a promising strategy for skin protection.

Indexed as

AMP-Activated Protein KinasesAntioxidantsAutophagyCyclooctanesLignansNF-E2-Related Factor 2Polycyclic CompoundsSkin AgingUltraviolet RaysAnimalsApoptosisCell SurvivalHumansMiceMice, Inbred ICROxidative StressAMP-Activated Protein KinasesAntioxidantsCyclooctanesLignansNF-E2-Related Factor 2Polycyclic Compoundsschizandrin AAMPKAutophagyNrf2PhotoagingSch A

Identifiers

PMID41801672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.