Evidence map›Paper›PMID 41801587›Full record

ArticleMedical oncology (Northwood, London, England)2026

Patient-derived spheroid culture: A promising in vitro model for drug screening in retinoblastoma.

Rathinavel Sethu Nagarajan, Sekaran Balaji, Usha Kim, Radhakrishnan Shanthi, Gowri Priya Chidambaranathan, Ramprasad Obula Giridhara Gopalan, Ayyasamy Vanniarajan

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Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Rathinavel Sethu NagarajanDepartment of Molecular Genetics, Aravind Medical Research Foundation, 1, Anna Nagar, Madurai, 625 020, Tamil Nadu, India.ORCID http://orcid.org/0009-0000-4699-1477
Sekaran BalajiDepartment of Molecular Genetics, Aravind Medical Research Foundation, 1, Anna Nagar, Madurai, 625 020, Tamil Nadu, India.
Usha KimDepartment of Orbit, Oculoplasty and Oncology, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Radhakrishnan ShanthiDepartment of Pathology, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Gowri Priya ChidambaranathanDepartment of Immunology and Stem Cell Biology, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Ramprasad Obula Giridhara GopalanDepartment of Proteomics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Ayyasamy VanniarajanDepartment of Molecular Genetics, Aravind Medical Research Foundation, 1, Anna Nagar, Madurai, 625 020, Tamil Nadu, India. vanniarajan@aravind.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In retinoblastoma (RB), the search for newer therapeutics is a thrust area for better disease management, and there is a lack of in vitro models that recapitulate the clinical scenario. Hence, we aim to establish RB patient-derived spheroid culture and evaluate its utility as an in vitro drug screening model. Initially we employed different media compositions to optimize the spheroid culture establishment. Sanger sequencing and Multiplex ligation dependent probe amplification were done to confirm the RB1 genotype of the spheroids. Drug responsiveness was assessed using CellTiter-Glo

Indexed as

Antineoplastic AgentsRetinal NeoplasmsRetinoblastomaSpheroids, CellularCarboplatinCell Culture TechniquesChild, PreschoolDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFemaleHumansInfantMaleRetinoblastoma Binding ProteinsTumor Cells, CulturedUbiquitin-Protein LigasesAntineoplastic AgentsCarboplatinRB1 protein, humanRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesDrug repurposingIn vitro modelRetinoblastomaSpheroid culture

Identifiers

PMID41801587

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