Trial reportEndocrine2026
Evaluation of a conversation aid for patients with thyroid nodules considering a biopsy: pilot multicenter randomized control trial.
Trial report in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463719 (Adequate Selection of Patients for Thyroid Biopsy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
importanceInadequate selection of patients for thyroid biopsy contributes and precedes thyroid cancer overdiagnosis.
objectiveTo assess the feasibility of a multicenter randomized trial evaluating a conversation aid for patients with thyroid nodules.
designPilot encounter level randomized trial.
settingTwo US academic centers.
participantsClinicians who routinely engaged in discussions with patients about thyroid nodules and their eligible patients, i.e., English-speaking adults (aged ≥ 18 years) presenting for initial evaluation of a thyroid nodule. Patients were excluded if they had hyperthyroidism, were pregnant, had already undergone a biopsy of the nodule of interest, or had received counseling for thyroid nodule management within the year before their visit.
interventionEncounters were randomized to either usual care alone or usual care plus a conversation aid. MAIN OUTCOME(S) AND MEASURE(S): The primary outcome was feasibility of implementing study procedures. Secondarily, we assessed the aids’ impact on shared decision-making and clinical outcomes. We used the Observing Patient Involvement in Decision Making (OPTION-12) scale to assess the observed extent to which clinicians sought to involve patients in decision making.
resultsDuring the study, we screened 531 patients scheduled for thyroid nodule evaluation and found 213 (40%) eligible; of these, 120 (56%) attended their clinic visit and were invited to participate. Of those, 90 (75%) agreed to participate. Post-visit surveys were completed by 98% of patients, and clinical visit recordings obtained for 99% of encounters. The trial included 43 patients in each arm, most of whom were women (80%), mean age 57 years (SD 16). Encounter duration averaged 22 min, in both groups. Compared to usual care alone, usual care plus conversation aid yielded higher OPTION-12 scores (34 vs. 21, p < 0.001), more frequent discussion of alternative approaches (91 vs. 65% p = 0.008), and fewer decisions to pursue nodule biopsy (40 vs. 51%, p = 0.386). CONCLUSIONS AND RELEVANCE: This study demonstrates the feasibility of procedures needed to conduct a multicenter randomized trial assessing the efficacy of a conversation aid. Preliminary outcomes suggest that the aid may favorably affect the care of patients with thyroid nodules.
trial registrationNCT04463719.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.