ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2026
Tissue characteristics in a traumatised immature necrotic incisor after unsuccessful regenerative endodontic treatment: an immunohistological case report.
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe present case report aimed to present an immunohistological analysis of newly formed intracanal tissues in a traumatised immature permanent incisor with pulp necrosis and apical periodontitis following RET. CASE DESCRIPTION: A 7-year-old girl sustained a combined traumatic dental injury, an uncomplicated crown fracture and lateral luxation, affecting an immature maxillary central incisor. The tooth subsequently developed pulpal necrosis and apical periodontitis and was treated with RET using calcium hydroxide as an intracanal medicament. A blood clot served as the scaffold, followed by placement of calcium silicate cement (Biodentine
resultsHistological and immunohistological analyses revealed a heterogeneous mixture of mineralised and connective tissues within the root canal space. The tissues demonstrated infiltration of fibroblast-like cells, resorptive cells, blood vessels and nerve fibres. Numerous fibrous cystic structures containing cholesterol crystals were identified in the middle third of the root canal.
conclusionThe newly formed intracanal tissues demonstrated limited similarity to intact odontogenic tissues. Both inflammatory root resorption and ankylosis-related replacement resorption, likely associated with the initial luxation injury, were observed. The presence of cholesterol crystal deposits represents a novel finding that may provide new insights into the biological processes occurring after RET. As cellular events following RET cannot be fully controlled clinically, the risk of unfavourable outcomes should be considered carefully, particularly in cases involving luxation injuries.
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