ArticleAbdominal radiology (New York)2026
Evaluating lymph node metastases in cervical cancer: the added value of T2/DWI MRI fusion compared to standard MRI alone and 18 F-FDG PET/CT.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the added diagnostic value of T2-weighted and diffusion-weighted imaging (DWI) fusion in MRI for detecting metastatic lymph nodes in cervical cancer, and to compare this fusion technique to 18 F-FDG PET/CT in terms of sensitivity and specificity.
methodsIn this retrospective single-center study, 69 patients with histologically confirmed cervical cancer underwent pelvic MRI, including T2-weighted and DWI sequences, as well as 18 F-FDG PET/CT. Fusion images combining T2 and high b-value DWI were generated and reviewed by experienced radiologists. The number and location of lymph nodes detected with conventional MRI, fused MRI, and PET/CT were recorded. Statistical analysis was performed using McNemar's test, with p < 0.05 considered statistically significant.
resultsFusion MRI identified additional lymph nodes in 16 of 69 patients (23.2%) that were not detected on MRI alone (p < 0.001). When comparing fusion MRI to PET/CT, 11 (15.9%) patients had lymph nodes detected or more accurately characterized by fusion MRI that PET/CT missed or misinterpreted, while only 1 case (1.4%) was better identified by PET/CT (p = 0.006).
conclusionFusion of T2-weighted and DWI MRI sequences improves the detection and characterization of metastatic lymph nodes in cervical cancer staging, surpassing both standard MRI and PET/CT in selected cases. This technique offers a non-invasive, accessible, and efficient enhancement to conventional imaging protocols, with the potential to influence treatment planning and improve patient outcomes.
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