ArticleNeuroradiology2026
Choroid plexus structural and functional abnormalities correlate with disease severity and cognition in cerebral small vessel disease.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeThe choroid plexus (CP) plays an interactive role in diverse pathophysiological mechanisms of cerebral small vessel disease (CSVD). We aimed to explore whether the CP has specific imaging or clinical consequences in CSVD by itself.
methodsA total of 90 patients with CSVD and 31 healthy controls (HCs) who underwent multiparameter MRI and neuropsychological tests, were retrospectively evaluated. The CP of the lateral ventricles was automatically segmented and manually corrected. The normalized CP volume, susceptibility and perfusion information of CP, and the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index relating to glymphatic efflux were obtained. Partial correlation and multiple linear regression analyses were used to assess the relationship between CP and disease severity and CSVD-related cognitive decline.
resultsPatients with CSVD had greater CP volume, lower susceptibility, reduced perfusion, and smaller DTI-ALPS indices (all p < 0.05). CP volume was correlated with white matter hyperintensities, lacunes, and CSVD burden (r = 0.237, p = 0.028; r= 0.228, p = 0.034; r = 0.320, p= 0.003). CP volume and perfusion showed correlations with specific cognitive domains (all p < 0.05), including memory, attention, and visuospatial functions. Interestingly, the susceptibility and arterial transit time of CP were related to DTI-ALPS in HC group (β = 0.542,p= 0.047; β=-0.605,p = 0.015), while the correlation vanished in CSVD group.
conclusionThe CP showed structural and functional abnormalities, which was related to CSVD disease severity and cognitive status, highlighting CP-targeted interventions as a potential therapeutic strategy. The uncoupling between CP and DTI-ALPS in CSVD patients suggests disrupted fluid homeostasis, warranting further validation via direct glymphatic imaging.
Indexed as
Identifiers
41801368What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.