Evidence map›Paper›PMID 41801344›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Sedative effects of physcion and its modulatory interaction with diazepam: in vivo and in silico evaluation.

Md Shadin, Md Shimul Bhuia, Mohammed Alfaifi, Abdullah H Altemani, Faisal H Altemani, Faisal Alsenani, Raihan Chowdhury, Muhammad Torequl Islam

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Md ShadinDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8105, Bangladesh.ORCID 0009-0000-1587-2838
Md Shimul BhuiaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8105, Bangladesh. shimulbhuia.pharm@gmail.com.ORCID 0000-0002-6179-9720
Mohammed AlfaifiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Abdullah H AltemaniDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Faisal H AltemaniDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, 71491, Tabuk, Saudi Arabia.
Faisal AlsenaniDepartment of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, 24381, Makkah, Saudi Arabia.
Raihan ChowdhuryDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8105, Bangladesh.
Muhammad Torequl IslamDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8105, Bangladesh. dmt.islam@gstu.edu.bd.ORCID 0000-0001-6392-3820

Funding

King Khalid University RGP1-112-46
6 · The paper itself

Abstract

Physcion (PHY), an anthraquinone derivative, has demonstrated various biological properties, including antioxidant and anti-inflammatory effects. This study aimed to evaluate the sedative activity of PHY in Swiss mice using in vivo and in silico approaches. The thiopental sodium (TS)-induced sleep model, fireplace test, and hole cross test were employed to assess sedation along with molecular docking studies. PHY significantly (p < 0.05) reduced sleep latency (17.29 ± 2.33 min) and increased sleep duration (162.85 ± 8.38 min) compared to controls at higher doses. It also significantly increased (p < 0.05) jump time and decreased the number of hole crosses. Co-administration of PHY with diazepam (DZP) enhanced sedation, while Co-administration with flumazenil (FLN) attenuated it, suggesting modulation of GABA

Indexed as

DiazepamEmodinHypnotics and SedativesSleepAnimalsBehavior, AnimalComputer SimulationDose-Response Relationship, DrugDrug InteractionsFlumazenilMaleMiceMolecular Docking SimulationReceptors, GABA-AThiopentalDiazepamEmodinFlumazenilHypnotics and SedativesReceptors, GABA-AThiopentalInsomniaMolecular dockingPhyscionSedative activity

Identifiers

PMID41801344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.