Evidence map›Paper›PMID 41801334›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Ocular adnexa follicular lymphoma: clinicopathological study of 23 patients.

Berik Kaliullayev, Patricia López-Pereira, Javier Martínez, Montse Gomà, María José Paúles, Maria Neus Fullana, Juan Azcárate, Hristo Iliev, Jan Bosch-Schips, Montserrat Cortés and 4 more

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Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Berik KaliullayevPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain. berikkaliullayev@bellvitgehospital.cat.ORCID http://orcid.org/0000-0001-9071-0919
Patricia López-PereiraHaematology Department, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.
Javier MartínezPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
Montse GomàPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
María José PaúlesPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
Maria Neus FullanaPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
Juan AzcáratePathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
Hristo IlievPathology Department, Girona University Hospital Dr. Josep Trueta, Girona, Spain.
Jan Bosch-SchipsPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain.
Montserrat CortésNuclear Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Cristina LópezPathology Department, Haematopathology Section, Hospital Clínic de Barcelona, Barcelona, Spain.
Maravillas AbiaOphthalmology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Guillermo FontOphthalmology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Fina ClimentPathology Department, Hospital Universitari de Bellvitge-IDIBELL, Feixa Llarga S/N. L'Hospitalet de Llobregat, Barcelona, 08907, Spain. fcliment@bellvitgehospital.cat.ORCID http://orcid.org/0000-0002-4360-8388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma (FL) spans both nodal and extranodal sites, with molecular characteristics that may vary by anatomical location. While nodal FL typically shows BCL2 rearrangement and frequent chromatin-modifying gene mutations (CREBBP, KMT2D), some extranodal FLs lack t(14;18)(q32:q21) and harbour distinct alterations, such as TNFRSF14 mutations. In our retrospective series of 23 ocular adnexal FL (OA FL) cases that include both primary and secondary involvement, an approximately equal distribution of BCL2-rearranged and non-rearranged cases was observed, underlining that the ocular localisation displays features of both conventional nodal and extranodal FL. Mutational analysis revealed a mix of mutations commonly seen in nodal and extranodal FL, with strong CD23 expression correlating with JAK/STAT pathway gene mutations. Most OA FLs followed an indolent course with good outcomes after local therapy, though transformation to diffuse large B-cell lymphoma occurred in a subset of two cases. Our results suggest that OA FL exhibits genetic heterogeneity, combining molecular features from both subtypes, and highlight the importance of thorough staging and individualised therapeutic and surveillance strategies for each patient.

Indexed as

Extranodal lymphomaFollicular lymphomaOcular adnexa

Identifiers

PMID41801334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.