ArticleJornal brasileiro de nefrologia
Acute kidney injury in patients undergoing cardiac transplantation: a cohort study on incidence and risk factors in the first three years of service implementation.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAcute kidney injury (AKI) is a common complication in the postoperative period of heart transplantation and is associated with unfavorable patient outcomes.
objectiveTo analyze the incidence of AKI in patients undergoing heart transplantation and to identify preoperative, intraoperative, and postoperative risk factors associated with its development.
methodsThis was a single-center retrospective cohort study including patients who underwent heart transplantation during the first three years of the program at a tertiary hospital in the State of São Paulo, from January 2020 to January 2023. Patients with chronic kidney disease (CKD) stages 4 or 5 and prior kidney transplantation were excluded.
resultsThe incidence of AKI was 48%. Logistic regression analysis demonstrated an association between AKI and the following factors: pre-existing CKD (OR = 3.155; 95% CI 1.343-6.340; p = 0.031), cold ischemia time (OR = 1.956; 95% CI 1.126-3.053; p = 0.042), and higher doses of norepinephrine in the first postoperative day (OR = 5.211; 95% CI 2.696-8.987; p = 0.028). There was no significant difference in mortality between patients who developed AKI and those who did not (58.3% vs. 38.5%; p = 0.09).
conclusionThe incidence of AKI was high (48%) in this population. The main risk factors for its development were pre-existing CKD, prolonged cold ischemia time, and higher doses of norepinephrine in the first postoperative day.
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