ArticleJournal of virology2026
Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice.
Matthew D Slein, Lesle M Jiménez, Iara M Backes, Evelyn M Turnbaugh, Callaghan R Garland, Scott W MacDonald, Alejandro B Balazs, David A Leib, Margaret E Ackerman
Abstract read
In one paragraphArticle in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Matthew D SleinDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID 0000-0001-8288-787X Lesle M JiménezDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Iara M BackesDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Evelyn M TurnbaughDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Callaghan R GarlandDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Scott W MacDonaldRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Alejandro B BalazsRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
David A LeibDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID 0000-0001-5539-8480 Margaret E AckermanDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID 0000-0002-4253-3476 Funding
VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI COEN, DONALD M · 2013 to 2023
$19.2MTransferred ImmunityU19AI145825 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI MARCHANT, ARNAUD · 2021 to 2025
$16.0MVIRAL & HOST FACTORS IN HERPETIC REACTIVATIONR01EY009083 · NEI · WASHINGTON UNIVERSITY · PI David A Leib · 1992 to 2026
$10.3MIMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5MChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2MPolyclonal Bi-Specific Vectored ImmunoTherapy to Functionally Cure HIV InfectionDP1DA060607 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI Alejandro Benjamin Balazs · 2024 to 2026
$3.2MUnderstanding and optimizing antibody-based interventions against neonatal HSV infectionR01AI176646 · NIAID · DARTMOUTH COLLEGE · PI Margaret E Ackerman, David A Leib · 2023 to 2026
$3.1MEngineering Humoral Immunity to Functionally Cure HIV InfectionDP2DA040254 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI BALAZS, ALEJANDRO BENJAMIN · 2015 to 2015
$2.6MEliminating the Immunogenicity of AAV Vectored HIV Antibody DeliveryR01AI174276 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Alejandro Benjamin Balazs · 2024 to 2026
$2.5MAAV Vectored Delivery of Broadly Neutralizing Antibodies with Optimal Innate Functionality Against HIVR01AI174875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BALAZS, ALEJANDRO BENJAMIN · 2023 to 2024
$1.6MMolecular characterization and modeling efficient antibody effector functionR01AI186995 · NIAID · DARTMOUTH COLLEGE · PI Margaret E Ackerman · 2025 to 2026
$884kMonoclonal antibody therapy for neonatal HSV infectionsR21AI147714 · NIAID · DARTMOUTH COLLEGE · PI LEIB, DAVID A · 2019 to 2020
$451kNEI NIH HHS R01 EY009083NIAID NIH HHS P01 AI098681NIAID NIH HHS R01 AI174276NIAID NIH HHS R01 AI174875NIAID NIH HHS R01 AI176646NIAID NIH HHS R01 AI186995NIAID NIH HHS R21 AI147714NIAID NIH HHS T32 AI007363NIAID NIH HHS U19 AI145825NIDA NIH HHS DP1 DA060607NIDA NIH HHS DP2 DA040254NIGMS NIH HHS R01 GM129325
6 · The paper itselfAbstract
Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a critical target for the host immune system with high potential relevance for vaccine design. Here, we investigated the mechanisms of protection for a panel of gB-specific monoclonal antibodies (mAbs) in a mouse model of neonatal HSV (nHSV) infection. Depending on dose, viral neutralization contributed, but Fc effector functions were critical for mAb-mediated protection against nHSV mortality. Moreover, adeno-associated virus-mediated
Indexed as
Antibodies, MonoclonalAntibodies, ViralHerpes SimplexHerpesvirus 1, HumanViral Envelope ProteinsAnimalsAnimals, NewbornAntibodies, NeutralizingDisease Models, AnimalFemaleHerpesvirus 2, HumanMicePregnancy Complications, InfectiousAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, Viralglycoprotein B, SimplexvirusViral Envelope Proteinsantibodyeffector functionherpesvirusmechanismneonatalneutralization
Identifiers
PMID41800909
PMCPMC13098214
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