Evidence map›Paper›PMID 41800648›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Contemporary outcomes of isolated liver and combined liver-lung transplantation for cystic fibrosis in children.

Ioannis A Ziogas, Victor Perim, Dor Yoeli, Alejandro Suarez-Pierre, Nicholas R Schmoke, Hunter B Moore, Julia M Boster, Michael R Narkewicz, Sarah A Taylor, Michael E Wachs and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ioannis A ZiogasDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-6742-6909
Victor PerimDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Dor YoeliDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Alejandro Suarez-PierreDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nicholas R SchmokeDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hunter B MooreAdventHealth Transplant Institute Porter, Denver, Colorado, USA.
Julia M BosterSection of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.
Michael R NarkewiczSection of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.
Sarah A TaylorSection of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.
Michael E WachsDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Megan A AdamsDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

None
6 · The paper itself

Abstract

objectiveTo compare isolated liver transplantation (LT) for cystic fibrosis (CF) versus other indications and versus combined liver-lung transplantation (CLLT) for CF in children and identify factors associated with survival.

methodsWe compared clinical and survival data after first isolated LT for CF versus other indications and versus CLLT for CF in children (<18 years) using United Network for Organ Sharing data (02/2002-12/2024).

resultsA total of 157 pediatric CF transplant recipients were included (LT: 145; CLLT: 12). Isolated CF LT recipients had higher total bilirubin (TB) than CLLT (median 1.6 vs. 0.7 mg/dL, p = 0.02). A higher proportion of CF transplant recipients with high TB levels (≥1.5 mg/dL) had ascites, encephalopathy, and required life support compared to those with low TB levels (<1.5 mg/dL). CF LT demonstrated superior patient survival versus CF CLLT (log-rank test, p = 0.02; 5-year: 89.1% vs. 72.2%), but inferior versus non-CF LT (log-rank test, p < 0.001; 5-year: 91.5%). Multivariable Cox regression showed increased risk of patient mortality and liver graft loss in CF CLLT recipients compared to isolated CF LT recipients (hazard ratio [HR] = 2.92, 95% confidence interval [95% CI]: 1.20-7.07, p = 0.02 and HR = 2.56, 95% CI: 1.09-5.98, p = 0.03, respectively) and recipients with higher TB levels (HR = 1.05, 95% CI: 1.01-1.10, p = 0.008 and HR = 1.05, 95% CI: 1.01-1.09, p = 0.008, respectively), when adjusting for recipient age, albumin and international normalized ratio (INR) at time of LT, ICU status, and liver graft type. Multivariable Cox regression of isolated LT recipients showed increased risk of patient mortality (HR = 2.03, 95% CI: 1.41-2.93, p < 0.001) and liver graft loss (HR = 1.54, 95% CI: 1.13-2.11, p = 0.006) for CF compared to non-CF etiologies, when adjusting for recipient age, albumin, INR, and TB at time of LT, ICU status, and liver graft type.

conclusionIsolated LT for CF was associated with superior survival compared to CLLT for CF, but inferior survival compared to LT for non-CF indications. Higher TB in CF may be a marker of inferior outcomes post-LT.

Indexed as

Cystic FibrosisLiver TransplantationLung TransplantationAdolescentBilirubinChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTreatment OutcomeBilirubinbilirubincirrhosislung transplantationpediatric liver transplantationunited network for organ sharing

Identifiers

PMID41800648
PMCPMC13446639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.