ArticleThe Canadian journal of urology2026
Association of tertiary lymphoid structures and benign lymphoepithelial lesions in NIH-category IV prostatitis: pathophysiological correlations.
Article in The Canadian journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Immune remodeling in chronic prostatitis: from microenvironment imbalance to targeted therapy.Frontiers in molecular biosciences · 2026Article
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Authors and funding
6 authors.
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Abstract
backgroundChronic inflammation is closely associated with the most common and socially significant prostate conditions, including benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis syndromes. NIH-category IV prostatitis (histologic prostatitis, HP) is defined as asymptomatic chronic inflammation of the prostate. The presence of lymphoid follicles, referred to as tertiary lymphoid structures (TLSs), along with benign lympho-epithelial lesions (BLELs), is among the key histological indicators of immune inflammation and can be assessed relatively easily. This study aimed to quantitatively assess TLSs and BLELs, as well as their relationship with the severity of HP.
methodsWe investigated TLSs and BLELs in 110 prostatic specimens, including inflammatory and normal tissues, within the context of common prostate pathologies such as BPH and PCa. HP was graded as low-grade (LG) or high-grade (HG) based on the severity of inflammation.
resultsTLSs were observed in 51 out of 110 cases (46.4%), while BLELs were identified in 78 cases (70.44%). Both TLSs and BLELs co-occurred in 45 cases (40.9%). Statistical analysis revealed a significant correlation between the presence of TLSs, BLELs (individually or combined), and HG-HP (p < 0.001).
conclusionsThis study is the first to quantitatively evaluate the immunopathologic patterns in the inflamed human prostate by analyzing the presence and co-occurrence of TLSs and BLELs. Their formation, likely triggered by antigenic stimuli and external factors, indicates a chronic inflammatory microenvironment. The strong association between TLSs, BLELs, and HG-HP underscores their potential role in HP aggressiveness. These findings suggest that TLSs and BLELs may be crucial contributors to the pathophysiology and morphogenesis of NIH-category IV prostatitis. Furthermore, TLS/BLEL formation may represent a hallmark of tissue autoimmunity, reflecting the immune or autoimmune phase of this prostatitis subtype.
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