ArticleFrontiers in microbiology2026
Hydrostatic pressure-enabled transformation in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Haloalkaliphilic Archaea that thrive in hypersaline and hyperalkaline environments represent valuable models for fundamental research as well as promising resources for biotechnological applications. However, fully exploiting their potential is hindered by the difficulty of their genetic manipulation, due to the limited availability of genetic tools and the use of a transformation protocol that remain slow and weakly efficient. This limits both industrial exploitation and the study of these organisms. In this study, we describe the development of a new, faster, and more efficient transformation method. It relies on the application of hydrostatic pressure, followed by a rapid return to atmospheric pressure, which generates transient pores in the cell membrane, facilitating the uptake of exogenous DNA. The results demonstrate that applying a pressure of 35 MPa in the presence of 1 M NaCl allows the rapid and efficient generation of transformants in
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