SynthesisFrontiers in microbiology2026
The impact of human immunodeficiency virus coinfection on mpox patients during the 2022 global outbreak: a systematic review and meta-analysis based on comparative observational studies.
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immune dysfunction drives adverse mpox outcomes among people living with human immunodeficiency virus: a systematic review and meta-analysis with CD4-based risk stratification.Frontiers in medicine · 2026Pooled it
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The mpox outbreak in 2022 posed a new challenge to the medical system. We aimed to study the impact of human immunodeficiency virus (HIV) coinfection on mpox patients. Methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Our study included 27 articles for meta-analysis and divided mpox patients into two groups: one group was HIV-positive, and the other group was HIV-negative. We found that the age of HIV-positive patients was significantly greater than that of HIV-negative patients (SMD = 0.35, 95% CI: 0.29-0.41) and that there were more men who had sex with men in the HIV-positive group (OR = 3.98, 95% CI: 3.04-5.21). Syphilis (OR = 2.66, 95% CI: 2.13-3.33), hepatitis B (OR = 3.94, 95% CI: 2.93-5.30), hepatitis C (OR = 5.71, 95% CI: 3.06-10.64), proctitis (OR = 1.52, 95% CI: 1.17-1.98), fever (OR = 1.15, 95% CI: 1.01-1.30), diarrhea (OR = 1.69, 95% CI: 1.03-2.77) and pustules (OR = 1.33, 95% CI: 1.08-1.62) were more common among HIV-positive patients. HIV coinfection seemed to be associated with a decrease in the CD4 Conclusion: Overall, HIV coinfection may influence the disease process and clinical indicators of mpox patients and is associated with more severe clinical outcomes. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251056729, PROSPERO registration number: CRD420251056729.
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