ArticleRSC medicinal chemistry2026
ZRMQ-22, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's disease.
Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by irreversible cognitive decline and memory loss. Targeting the kinase DYRK1A has emerged as a promising therapeutic strategy, as it plays a critical role in multiple key AD pathologies, including tau phosphorylation, β-amyloid (Aβ) production, and the regulation of neuroinflammatory processes. In this study, a series of novel quinazoline derivatives were designed and synthesized as DYRK1A inhibitors. Through preliminary anti-neuroinflammatory screening in a lipopolysaccharide (LPS)-induced BV2 microglial cell model, ZRMQ-22 was identified as a promising candidate that targets neuroinflammatory pathways in AD. This compound exhibits potent nanomolar-range inhibitory activity against DYRK1A, with an IC
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