Observational studyDrug design, development and therapy2026
Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Intravenous Vancomycin in Intracranial Hemorrhage Patients with External Ventricular Drains: Implications for Dosing and Therapeutic Drug Monitoring.
Observational study in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Vancomycin is frequently used to treat central nervous system (CNS) infections, yet its cerebrospinal fluid (CSF) penetration remains poorly characterized in patients with intracranial hemorrhage (ICH) requiring external ventricular drains (EVDs). Methods: A prospective observational study was conducted on nine neurosurgical patients with ICH and EVDs receiving intravenous vancomycin. Plasma and CSF samples were collected at predefined time points and analyzed by validated assays. Noncompartmental analysis, regression modeling, and nonlinear mixed-effects pharmacokinetic (PK) modeling were performed. Results: The AUC Conclusion: To our knowledge, this is the first study reporting real-world data of vancomycin CSF penetration in Taiwanese neurosurgical patients. These findings provide a critical PK foundation for developing future model-informed precision dosing strategies and validating surrogate TDM markers in this neurocritical care population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.