ArticleDrug design, development and therapy2026
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, creating an urgent need to elucidate its pathogenesis and develop effective therapeutic strategies. Methods: In this study, we established obese mouse models using distinct dietary patterns. We then employed 16S rRNA sequencing and metabolomics to profile gut microbiota composition and identify differential metabolites in serum and intestinal contents. Using Limited proteolysis mass spectrometry, co-immunoprecipitation mass spectrometry and luciferase reporter assays were used to identify the downstream molecular mechanisms. Results: Our findings revealed that the abundance of hippuric acid (HA) was significantly decreased in the serum and gut of obese C57BL/6 mice, and it positively correlated with the abundance of Conclusion: We demonstrate a novel mechanism for regulating hepatic lipid metabolism through HA/UGDH/FOXK1/CD36 pathway. This study provides evidence supporting the potential of HA as a therapeutic metabolite for MASLD. Moreover, these results are derived from preclinical murine models, and further clinical studies are warranted to validate the efficacy of HA.
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