Evidence map›Paper›PMID 41800262›Full record

ArticleInternational journal of biological sciences2026

DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence.

Pengbo Wang, Liming Yu, Kexin Cao, Xiaofan Guo, Lufan Sun, Shu Zhang, Tong Zhao, Yao Yu, Mengyao Xiong, Chang Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pengbo WangDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Liming YuState Key Laboratory of Frigid Zone Cardiovascular Disease, Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, 83 Wenhua Road, Shenyang City 110016, P. R. China.
Kexin CaoDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Xiaofan GuoDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Lufan SunDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Shu ZhangDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Tong ZhaoDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Yao YuDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Mengyao XiongDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Chang LiuDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Naijin ZhangDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Yingxian SunDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Guozhe SunDepartment of Cardiology, First Hospital of China Medical University, Shenyang City, P. R. China.
Liu CaoClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA polymerase gamma (Polγ), the sole polymerase for mitochondrial DNA (mtDNA), emerges as a critical regulator of metabolism-associated senescence. While lysine acetylation represents a key post-translational modification (PTM) influencing mitochondrial function, its mechanistic role in Polγ-mediated vascular aging remains undefined. Through combinatorial approaches employing

Indexed as

Cellular SenescenceDNA Polymerase gammaMitochondriaAcetylationAnimalsDNA, MitochondrialHomeostasisHumansMiceMyocytes, Smooth MuscleDNA, MitochondrialDNA Polymerase gammaAcetylationDNA polymerase gammahuman aortic smooth muscle cellsmitochondrial homeostasissenescence

Identifiers

PMID41800262
PMCPMC12965149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.