Evidence map›Paper›PMID 41800191›Full record

ArticleBioinorganic chemistry and applications2026

Substitution Kinetics, DNA/BSA Interactions, Cytotoxicity Evaluation and Computational Analysis of [

Phakamani C Dlamini, Thato T Medupe, Lucy W Macharia, Karabo Serala, Sharon Prince, Gregory S Smith, Irvin N Booysen, Allen Mambanda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinorganic chemistry and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Phakamani C DlaminiSchool of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01 Scottsville, Pietermaritzburg, 3209, South Africa, ukzn.ac.za.ORCID https://orcid.org/0000-0002-7695-0657
Thato T MedupeDepartment of Chemistry, University of Cape Town, Private Bag X3 Rondebosch, Cape Town, 7701, South Africa, uct.ac.za.
Lucy W MachariaDepartment of Human Biology, Faculty of Health Science, University of Cape Town, Observatory, Cape Town, 7925, South Africa, uct.ac.za.ORCID https://orcid.org/0000-0002-5356-9247
Karabo SeralaDepartment of Human Biology, Faculty of Health Science, University of Cape Town, Observatory, Cape Town, 7925, South Africa, uct.ac.za.
Sharon PrinceDepartment of Human Biology, Faculty of Health Science, University of Cape Town, Observatory, Cape Town, 7925, South Africa, uct.ac.za.ORCID https://orcid.org/0000-0002-6975-5255
Gregory S SmithDepartment of Chemistry, University of Cape Town, Private Bag X3 Rondebosch, Cape Town, 7701, South Africa, uct.ac.za.ORCID https://orcid.org/0000-0002-2892-5481
Irvin N BooysenSchool of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01 Scottsville, Pietermaritzburg, 3209, South Africa, ukzn.ac.za.ORCID https://orcid.org/0000-0001-9680-5978
Allen MambandaSchool of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01 Scottsville, Pietermaritzburg, 3209, South Africa, ukzn.ac.za.ORCID https://orcid.org/0000-0002-8113-3643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for metal-based anticancer agents with improved efficacy and reduced side effects is ongoing. The activities of these anticancer drugs depend on their aqueous stability, substitutional reactivity at target sites (cytotoxicity) and nontarget sites (toxicity), as well as their transportation and cell bioavailability. In this study, six square-planar Pt(II) and Pd(II) complexes (Pt/PdL1Cl-3), all bearing the bis(azaaryl)amine (azaaryl = quinoline or phenanthridine) chelating ligands, were synthesised and characterised by various spectroscopic methods. Their biochemical interactions with bovine serum albumin (BSA)/deoxyribonucleic acid (DNA) and rates of ligand exchange with biological nucleophiles (guanine and thiourea) were probed spectrophotometrically. DFT-optimised molecular structures in Gaussian 9 were computed. Molecular docking simulations of the optimised structures at the receptors of CT-DNA, BSA and relevant enzymes that upregulate cancer progression were conducted. The metal complexes showed moderate to strong interactions (

Indexed as

anticancer cytotoxicityDNA/BSA interactionsmolecular dockingPalladium II complexesPlatinum IIsubstitution kinetics

Identifiers

PMID41800191
PMCPMC12960781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.