ReviewFrontiers in bioengineering and biotechnology2026
The mediating role of sacral slope in the relationship between lumbar lordosis and knee alignment in knee osteoarthritis: an imaging study.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biomechanics of knee osteoarthritis from local knee loading to whole kinetic chain imbalance: a narrative review.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the association between lumbar lordosis (LL) and the sagittal hip-knee-ankle angle (sHKA) in patients with knee osteoarthritis (KOA) and to quantify the mediating effect of the sacral slope (SS). Methods: This study enrolled 507 participants (left-side 302, right-side 205). Lateral full-length X-ray films of the lower extremities in weight-bearing position were collected from the research participants to measure radiological parameters such as lumbar lordosis (LL), sacral slope (SS), and sagittal hip-knee-ankle angle (sHKA), and SF-12 (12-items Short Form Health Survey) and WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores were also collected. Correlation analysis and Bootstrap mediation effect analysis were performed. Results: Among the 507 KOA participants, LL was positively correlated with SS, HKA, sHKA, and SF-12 scores, and negatively correlated with JLCA and WOMAC scores. The mediation analysis revealed that SS accounted for 10.74% of the total association of LL on sHKA. Conclusion: In patients with KOA, LL is closely related to sHKA, and this statistical association may be partially mediated by SS. This highlights the importance of adopting a "spine-pelvis-knee" perspective when assessing and treating KOA.
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