ArticleFrontiers in bioengineering and biotechnology2026
Metformin-loaded J-AuPPS for infected diabetic wound treatment.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Infected diabetic wounds pose a significant clinical challenge owing to the complex wound microenvironment. Various multifunctional synergistic therapeutic nanomaterials have been successfully developed to treat diabetic infected wounds. Objective: A Janus Au-porphyrin polymersome heterostructure loaded with metformin (Met@J-AuPPS) is constructed and presented. Methods: Porphyrin polymersome vesicles loaded with metformin (Met@PPS) was synthesized by supramolecular polymerization enhanced self-assembly. Metformin-loaded Janus gold-porphyrin polymersome (Met@J-AuPPS) was synthesized by photocatalytic synthesis method. Transmission electron microscope (TEM), scanning electron microscope (SEM), UV-vis absorption spectrum and ELISA experiment were used to detect the morphology, structure, photothermal properties and drug release properties of Met@J-AuPPS. The effects of Met@J-AuPPS on the proliferation and activity of HUVECs were detected by CCK-8 test, scratch test, Transwell test and tube formation test. The antibacterial and antibiofilm abilities of Met@J-AuPPS were detected by blood plate test, crystal violet staining, SEM of biofilm and bacterial live/dead staining. Imaging and histological staining were used to detect the efficacy of Met@J-AuPPS in treating diabetic wound infections Results: Excellent photothermal antibacterial performance against gram-positive methicillin-resistant Conclusion: This study presents an innovative therapeutic strategy for diabetic wound infections and demonstrates that Met@J-AuPPS has potential as a multifunctional and upgradeable nanoplatform for further biomedical applications.
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