Evidence map›Paper›PMID 41800134›Full record

ArticlePeerJ2026

Relationship between blood pressure level and activity of renin-aldosterone axis in patients with essential hypertension-a retrospective study.

Peijuan Li, Bo Liao, Zhaoquan Yang, Jiulin Zhang, Kun Chen, Zhipeng Li

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Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Peijuan LiGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Bo LiaoGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Zhaoquan YangGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Jiulin ZhangDepartment of Internal Medicine, Minzu Central Health Center, Haoba Town, Junlian County, Yibin, China.
Kun ChenGeneral Department, Health Center, Jiangan Town, Jiangan County, Yibin, China.
Zhipeng LiGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A study indicates that elevated aldosterone levels increase the risk of hypertension by 16%. This retrospective cohort study examines the relationship between blood pressure and renin-aldosterone levels in patients with essential hypertension (EH), aiming to elucidate the clinical features and risk factors of inappropriate hyperaldosteronism in Chinese individuals with essential hypertension. Methods: Clinical data of 309 EH patients were analyzed. The participants were divided into three groups with a high (H)/medium (M)/low (L) blood pressure level: Group H (BP≥160 / (or) 100 mmHg, Results: Among the 309 EH patients, 65 cases (21.04%) had elevated aldosterone levels, and 94 cases (30.42%) had increased renin activity. The diastolic blood pressure of patients with elevated aldosterone levels was higher than that of patients with normal or decreased aldosterone levels (100 Conclusion: The increase in aldosterone levels is relatively common among EH patients in China. The increase in aldosterone levels is correlated with the elevation of diastolic blood pressure. The elevated aldosterone levels are an independent risk factor for the increase in diastolic blood pressure in EH patients.

Indexed as

AldosteroneBlood PressureHypertensionReninRenin-Angiotensin SystemAdultAgedEssential HypertensionFemaleHumansHyperaldosteronismMaleMiddle AgedRetrospective StudiesRisk FactorsAldosteroneReninDiastolic blood pressureEssential hypertensionInappropriate hyperaldosteronemia

Identifiers

PMID41800134
PMCPMC12965167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.