ArticlePeerJ2026
Pathological features of BRCA-mutated breast cancer in Shenzhen, China: a single-center study.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
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Abstract
Background: Most studies on breast cancer susceptibility gene (BRCA) mutations have focused on Caucasian populations in Europe and North America. Currently, there is a lack of literature and data research in related fields in Shenzhen, China, and even in Guangdong Province. This study aims to establish a registry of BRCA mutation carriers by analyzing and comparing the pathological features of breast cancer patients carrying and not carrying BRCA mutations in the Shenzhen area. Methods: Blood samples were collected from 406 breast cancer patients who met the inclusion criteria (from July 2016 to November 2024) and genetic testing was performed using next-generation sequencing (NGS) technology. Patients were divided into two groups: BRCA mutation group with 54 cases and BRCA non-mutation group with 352 cases. A retrospective analysis was conducted on patient data collected from the health information system of Shenzhen People's Hospital, including demographic data, clinical pathological characteristics, and variables related to molecular typing. We used SPSS software for statistical analysis of the data. Results: In 406 breast cancer patients, the average age of the BRCA mutation group was 39.3 ± 9.2 years, while the average age of the BRCA non-mutation group was 41.8 ± 8.8 years. The proportion of tumors ≤ 2 cm in the mutation group is 72.2%, higher than the 53.1% in the non-mutation group ( Conclusions: Compared to BRCA non-mutated patients, BRCA mutated patients in Shenzhen have smaller tumor volumes, with pathological grades mainly at grade 3, and molecular subtypes predominantly being triple-negative breast cancer.
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